Pregnancy profiles in the common bottlenose dolphin (Tursiops truncatus): Clinical biochemical and hematological variations during healthy gestation and a successful outcome

The physiological demands of pregnancy inevitably result in changes of both biochemical and hematological parameters as the fetus develops. Alterations in blood parameters have been observed to shift according to both trimester and species, to support fetal physiological needs and maternal basal req...

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Bibliographic Details
Published in:Theriogenology 2020-01, Vol.142, p.92-103
Main Authors: Barratclough, Ashley, Gomez, Forrest M., Morey, Jeanine S., Deming, Alissa, Parry, Celeste, Meegan, Jennifer M., Carlin, Kevin P., Schwacke, Lori, Venn-Watson, Stephanie, Jensen, Eric D., Smith, Cynthia R.
Format: Article
Language:English
Subjects:
Biochemistry
Common bottlenose dolphin
Gestation
Hematology
Pregnancy
Tursiops truncatus
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Summary:The physiological demands of pregnancy inevitably result in changes of both biochemical and hematological parameters as the fetus develops. Alterations in blood parameters have been observed to shift according to both trimester and species, to support fetal physiological needs and maternal basal requirements. Establishing normal reference ranges for each stage in gestation is important to facilitate diagnosis of underlying health concerns and prevent over-diagnosing abnormalities. Despite bottlenose dolphins (Tursiops truncatus) being one of the most highly studied cetaceans, the blood profile changes occurring as a result of pregnancy have not been previously described. A retrospective analysis was performed from blood samples obtained from 42 successful pregnancies from 20 bottlenose dolphins in a managed population over 30 years. Samples were compared to non-pregnant states and among trimesters of pregnancy. Blood profile fluctuations occurred throughout gestation, however significant alterations predominantly occurred between the 2nd and 3rd trimester. Hematological changes from the 2nd to the 3rd trimester included a decrease in lymphocytes, decrease in platelet count, and hemoconcentration with increased hematocrit and hemoglobin. Biochemical changes in the 3rd trimester included significant reductions in ALKP (alkaline phosphatase), ALT (alanine aminotransferase) and AST (aspartate aminotransferase) with significant increases observed in albumin, globulins, total protein, cholesterol, triglycerides and CO2. It’s important to note that despite significant shifts occurring between the 2nd and 3rd trimester, there was no significant change in platelets, hematocrit, hemoglobin, lymphocytes or CO2 between non-pregnant and 3rd trimester blood samples. The normal reference ranges for each trimester established herein, will enable future identification of abnormalities occurring during pregnancy and help improve our understanding of factors potentially influencing a failed or successful pregnancy outcome. •HCT, HGB, RBC normally increase significantly during 3rd trimester.•Total WBC should remain consistent throughout all three trimesters.•Inflammatory hemogram of ALKP decreasing significantly in 3rd trimester is expected.•Total protein, albumin and globulins increase consistently throughout gestation.
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2019.09.028