Interferons: A molecular switch between damage and repair in ageing and Alzheimer’s disease

•No cure for Alzheimer’s disease exists, but the interest in inflammation in Alzheimer’s disease is growing.•The balance between type I and type II IFNs plays an important role in the immune surveillance at the choroid plexus.•Aging and Alzheimer’s disease are associated with a disbalance between ty...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2019-10, Vol.183, p.111148-111148, Article 111148
Main Authors: Gorlé, N., Vandenbroucke, R.E.
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Choroid plexus
Inflammation
Interferons
Type I IFN
Type II IFN
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Summary:•No cure for Alzheimer’s disease exists, but the interest in inflammation in Alzheimer’s disease is growing.•The balance between type I and type II IFNs plays an important role in the immune surveillance at the choroid plexus.•Aging and Alzheimer’s disease are associated with a disbalance between type I and type II IFNs. Alzheimer’s disease was first described over 100 years ago, yet it remains incurable and affects 44 million people worldwide. Traditionally, research has largely focused on the amyloid cascade hypothesis, but interest in the importance of inflammation in the progression of the disease has recently been increasing. Interferons, a large family of cytokines that trigger the immune system, are believed to play a crucial role in the pathology of Alzheimer’s disease. This review focuses on how interferons affect the brain during ageing and whether they could be candidate therapeutic targets for the treatment of Alzheimer’s disease.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2019.111148