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Adventitious root cultures of Oplopanax elatus inhibit LPS-induced inflammation via suppressing MAPK and NF-κB signaling pathways
Bioreactor-cultured adventitious roots (ARs) of the endangered medicinal plant Oplopanax elatus Nakai is a novel alternative plant material. To utilize ARs in the product production, the present study investigated the anti-inflammatory effect of O. elatus ARs. In the in vivo experiment, lipopolysacc...
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| Published in: | In vitro cellular & developmental biology. Animal 2019-10, Vol.55 (9), p.766-775 |
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| container_title | In vitro cellular & developmental biology. Animal |
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| creator | Tian, Wen Piao, Xuan-Mei Yin, Cheng-Ri Jiang, Xiao-Long Sun, Hao-Ding An, Xiao-Li Jiang, Jun Lian, Mei-Lan |
| description | Bioreactor-cultured adventitious roots (ARs) of the endangered medicinal plant
Oplopanax elatus
Nakai is a novel alternative plant material. To utilize ARs in the product production, the present study investigated the anti-inflammatory effect of
O. elatus
ARs. In the
in vivo
experiment, lipopolysaccharide (LPS)-induced acute lung injury disease model was established and several inflammatory indexes were determined. For the LPS-stimulated mice, after pretreatment of AR crude extract (200 mg/kg), cell infiltration in lungs was decreased, the production of proinflammatory mediators, including nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and 1β in the bronchoalveolar lavage fluid was evidently reduced, which indicated that
O. elatus
ARs had an anti-inflammatory effect. In the
in vitro
experiment, ethyl acetate (EtOAc) fractions (12.5, 25, and 50 μg/mL) were used to treat LPS-induced peritoneal macrophages (PMs) of mice. The production of NO, prostaglandin E
2
, TNF-α, IL-6, and IL-1β in LPS-stimulated PMs was obviously inhibited (
p
|
| doi_str_mv | 10.1007/s11626-019-00396-7 |
| format | article |
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Oplopanax elatus
Nakai is a novel alternative plant material. To utilize ARs in the product production, the present study investigated the anti-inflammatory effect of
O. elatus
ARs. In the
in vivo
experiment, lipopolysaccharide (LPS)-induced acute lung injury disease model was established and several inflammatory indexes were determined. For the LPS-stimulated mice, after pretreatment of AR crude extract (200 mg/kg), cell infiltration in lungs was decreased, the production of proinflammatory mediators, including nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and 1β in the bronchoalveolar lavage fluid was evidently reduced, which indicated that
O. elatus
ARs had an anti-inflammatory effect. In the
in vitro
experiment, ethyl acetate (EtOAc) fractions (12.5, 25, and 50 μg/mL) were used to treat LPS-induced peritoneal macrophages (PMs) of mice. The production of NO, prostaglandin E
2
, TNF-α, IL-6, and IL-1β in LPS-stimulated PMs was obviously inhibited (
p
< 0.05) after pretreatment with EtOAc fractions, and the expression of the inducible nitric oxide synthase and cyclooxygenase were also suppressed. To clarify the anti-inflammatory mechanism, effects of EtOAc fraction on changes of proteins related to the pathways of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) were investigated. The phosphorylation of extracellular regulated protein kinases, c-jun n-terminal kinase, and p38 MAPK in LPS-induced PMs was inhibited after pretreatment of EtOAc fractions. In addition, EtOAc fractions enhanced inhibitor of nuclear factor-kappa B-α expression and decreased nuclear translocation of p65 NF-κB. Thus, EtOAc from
O. elatus
ARs is involved in regulating MAKP and NF-κB signaling pathways to inhibit LPS-induced inflammation.</description><identifier>ISSN: 1071-2690</identifier><identifier>EISSN: 1543-706X</identifier><identifier>DOI: 10.1007/s11626-019-00396-7</identifier><identifier>PMID: 31529418</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetic acid ; Alveoli ; Animal Genetics and Genomics ; Animals ; Biomedical and Life Sciences ; Bioreactors ; Bronchus ; c-Jun protein ; Cell Biology ; Cell Culture ; Developmental Biology ; Endangered plants ; Ethyl acetate ; Herbal medicine ; Humans ; In vivo methods and tests ; Inflammation ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - genetics ; Inflammation - pathology ; Interleukin 6 ; Interleukins ; JNK protein ; Kinases ; Life Sciences ; Lipopolysaccharides ; Lipopolysaccharides - toxicity ; Lung diseases ; Lungs ; Macrophages ; MAP kinase ; Medicinal plants ; Metastases ; Mice ; Mitogen-Activated Protein Kinase Kinases - genetics ; NF-kappa B - genetics ; NF-κB protein ; Nitric oxide ; Nitric-oxide synthase ; Nuclear transport ; Oplopanax ; Oplopanax - chemistry ; Peritoneum ; Phosphorylation ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Pretreatment ; Prostaglandin E2 ; Prostaglandin endoperoxide synthase ; Proteins ; Signal transduction ; Signal Transduction - drug effects ; Signaling ; Stem Cells ; Transcription factors ; Translocation ; Tumor necrosis factor-TNF</subject><ispartof>In vitro cellular & developmental biology. Animal, 2019-10, Vol.55 (9), p.766-775</ispartof><rights>The Society for In Vitro Biology 2019</rights><rights>Copyright Society for In Vitro Biology 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-b89afe1204bb6ef95148c8bd0ceb2af9b099ad211ce95613885f6299aedc3afb3</citedby><cites>FETCH-LOGICAL-c375t-b89afe1204bb6ef95148c8bd0ceb2af9b099ad211ce95613885f6299aedc3afb3</cites><orcidid>0000-0003-4527-2061</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31529418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Wen</creatorcontrib><creatorcontrib>Piao, Xuan-Mei</creatorcontrib><creatorcontrib>Yin, Cheng-Ri</creatorcontrib><creatorcontrib>Jiang, Xiao-Long</creatorcontrib><creatorcontrib>Sun, Hao-Ding</creatorcontrib><creatorcontrib>An, Xiao-Li</creatorcontrib><creatorcontrib>Jiang, Jun</creatorcontrib><creatorcontrib>Lian, Mei-Lan</creatorcontrib><title>Adventitious root cultures of Oplopanax elatus inhibit LPS-induced inflammation via suppressing MAPK and NF-κB signaling pathways</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell.Dev.Biol.-Animal</addtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>Bioreactor-cultured adventitious roots (ARs) of the endangered medicinal plant
Oplopanax elatus
Nakai is a novel alternative plant material. To utilize ARs in the product production, the present study investigated the anti-inflammatory effect of
O. elatus
ARs. In the
in vivo
experiment, lipopolysaccharide (LPS)-induced acute lung injury disease model was established and several inflammatory indexes were determined. For the LPS-stimulated mice, after pretreatment of AR crude extract (200 mg/kg), cell infiltration in lungs was decreased, the production of proinflammatory mediators, including nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and 1β in the bronchoalveolar lavage fluid was evidently reduced, which indicated that
O. elatus
ARs had an anti-inflammatory effect. In the
in vitro
experiment, ethyl acetate (EtOAc) fractions (12.5, 25, and 50 μg/mL) were used to treat LPS-induced peritoneal macrophages (PMs) of mice. The production of NO, prostaglandin E
2
, TNF-α, IL-6, and IL-1β in LPS-stimulated PMs was obviously inhibited (
p
< 0.05) after pretreatment with EtOAc fractions, and the expression of the inducible nitric oxide synthase and cyclooxygenase were also suppressed. To clarify the anti-inflammatory mechanism, effects of EtOAc fraction on changes of proteins related to the pathways of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) were investigated. The phosphorylation of extracellular regulated protein kinases, c-jun n-terminal kinase, and p38 MAPK in LPS-induced PMs was inhibited after pretreatment of EtOAc fractions. In addition, EtOAc fractions enhanced inhibitor of nuclear factor-kappa B-α expression and decreased nuclear translocation of p65 NF-κB. Thus, EtOAc from
O. elatus
ARs is involved in regulating MAKP and NF-κB signaling pathways to inhibit LPS-induced inflammation.</description><subject>Acetic acid</subject><subject>Alveoli</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Bioreactors</subject><subject>Bronchus</subject><subject>c-Jun protein</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Developmental Biology</subject><subject>Endangered plants</subject><subject>Ethyl acetate</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - genetics</subject><subject>Inflammation - pathology</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>JNK protein</subject><subject>Kinases</subject><subject>Life Sciences</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Macrophages</subject><subject>MAP kinase</subject><subject>Medicinal plants</subject><subject>Metastases</subject><subject>Mice</subject><subject>Mitogen-Activated Protein Kinase Kinases - genetics</subject><subject>NF-kappa B - genetics</subject><subject>NF-κB protein</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Nuclear transport</subject><subject>Oplopanax</subject><subject>Oplopanax - chemistry</subject><subject>Peritoneum</subject><subject>Phosphorylation</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Pretreatment</subject><subject>Prostaglandin E2</subject><subject>Prostaglandin endoperoxide synthase</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Signaling</subject><subject>Stem Cells</subject><subject>Transcription factors</subject><subject>Translocation</subject><subject>Tumor necrosis factor-TNF</subject><issn>1071-2690</issn><issn>1543-706X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuFSEUhonR2Fp9AReGxE03KAfuMLC8NlZNr7aJmrgjDAO3NDPMCExrtz6WD-EzSXurJi5kAznnOz-QD6GnQF8Ape3LDCCYIBQUoZQrQdp7aB-aFSctFV_u1zNtgTCh6B56lPMFrUuBeIj2ODRMrUDuo-_r_tLFEkqYlozTNBVsl6EsyWU8eXw6D9NsovmG3WBKJUI8D10oeHP2kYTYL9b1teYHM46mZkR8GQzOyzzXgBziFr9fn51gE3v84Zj8_PEK57CNZrjpzKacX5nr_Bg98GbI7sndfoA-H7_-dPSWbE7fvDtab4jlbVNIJ5XxDhhddZ1wXjWwklZ2PbWuY8arjiplegZgnWoEcCkbL1itud5y4zt-gA53uXOavi4uFz2GbN0wmOjq5zVjilPKQKqKPv8HvZiWVN9dKU4lA6W4rBTbUTZNOSfn9ZzCaNK1BqpvDOmdIV0N6VtDuq1Dz-6il250_Z-R30oqwHdArq24denv3f-J_QV_QJ6o</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Tian, Wen</creator><creator>Piao, Xuan-Mei</creator><creator>Yin, Cheng-Ri</creator><creator>Jiang, Xiao-Long</creator><creator>Sun, Hao-Ding</creator><creator>An, Xiao-Li</creator><creator>Jiang, Jun</creator><creator>Lian, Mei-Lan</creator><general>Springer US</general><general>Society for In Vitro Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4527-2061</orcidid></search><sort><creationdate>20191001</creationdate><title>Adventitious root cultures of Oplopanax elatus inhibit LPS-induced inflammation via suppressing MAPK and NF-κB signaling pathways</title><author>Tian, Wen ; Piao, Xuan-Mei ; Yin, Cheng-Ri ; Jiang, Xiao-Long ; Sun, Hao-Ding ; An, Xiao-Li ; Jiang, Jun ; Lian, Mei-Lan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-b89afe1204bb6ef95148c8bd0ceb2af9b099ad211ce95613885f6299aedc3afb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetic acid</topic><topic>Alveoli</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Bioreactors</topic><topic>Bronchus</topic><topic>c-Jun protein</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>Developmental Biology</topic><topic>Endangered plants</topic><topic>Ethyl acetate</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - genetics</topic><topic>Inflammation - pathology</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>JNK protein</topic><topic>Kinases</topic><topic>Life Sciences</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Macrophages</topic><topic>MAP kinase</topic><topic>Medicinal plants</topic><topic>Metastases</topic><topic>Mice</topic><topic>Mitogen-Activated Protein Kinase Kinases - genetics</topic><topic>NF-kappa B - genetics</topic><topic>NF-κB protein</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Nuclear transport</topic><topic>Oplopanax</topic><topic>Oplopanax - chemistry</topic><topic>Peritoneum</topic><topic>Phosphorylation</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Pretreatment</topic><topic>Prostaglandin E2</topic><topic>Prostaglandin endoperoxide synthase</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Signaling</topic><topic>Stem Cells</topic><topic>Transcription factors</topic><topic>Translocation</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Wen</creatorcontrib><creatorcontrib>Piao, Xuan-Mei</creatorcontrib><creatorcontrib>Yin, Cheng-Ri</creatorcontrib><creatorcontrib>Jiang, Xiao-Long</creatorcontrib><creatorcontrib>Sun, Hao-Ding</creatorcontrib><creatorcontrib>An, Xiao-Li</creatorcontrib><creatorcontrib>Jiang, Jun</creatorcontrib><creatorcontrib>Lian, Mei-Lan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>In vitro cellular & developmental biology. Animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Wen</au><au>Piao, Xuan-Mei</au><au>Yin, Cheng-Ri</au><au>Jiang, Xiao-Long</au><au>Sun, Hao-Ding</au><au>An, Xiao-Li</au><au>Jiang, Jun</au><au>Lian, Mei-Lan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adventitious root cultures of Oplopanax elatus inhibit LPS-induced inflammation via suppressing MAPK and NF-κB signaling pathways</atitle><jtitle>In vitro cellular & developmental biology. Animal</jtitle><stitle>In Vitro Cell.Dev.Biol.-Animal</stitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>55</volume><issue>9</issue><spage>766</spage><epage>775</epage><pages>766-775</pages><issn>1071-2690</issn><eissn>1543-706X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Bioreactor-cultured adventitious roots (ARs) of the endangered medicinal plant
Oplopanax elatus
Nakai is a novel alternative plant material. To utilize ARs in the product production, the present study investigated the anti-inflammatory effect of
O. elatus
ARs. In the
in vivo
experiment, lipopolysaccharide (LPS)-induced acute lung injury disease model was established and several inflammatory indexes were determined. For the LPS-stimulated mice, after pretreatment of AR crude extract (200 mg/kg), cell infiltration in lungs was decreased, the production of proinflammatory mediators, including nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6, and 1β in the bronchoalveolar lavage fluid was evidently reduced, which indicated that
O. elatus
ARs had an anti-inflammatory effect. In the
in vitro
experiment, ethyl acetate (EtOAc) fractions (12.5, 25, and 50 μg/mL) were used to treat LPS-induced peritoneal macrophages (PMs) of mice. The production of NO, prostaglandin E
2
, TNF-α, IL-6, and IL-1β in LPS-stimulated PMs was obviously inhibited (
p
< 0.05) after pretreatment with EtOAc fractions, and the expression of the inducible nitric oxide synthase and cyclooxygenase were also suppressed. To clarify the anti-inflammatory mechanism, effects of EtOAc fraction on changes of proteins related to the pathways of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) were investigated. The phosphorylation of extracellular regulated protein kinases, c-jun n-terminal kinase, and p38 MAPK in LPS-induced PMs was inhibited after pretreatment of EtOAc fractions. In addition, EtOAc fractions enhanced inhibitor of nuclear factor-kappa B-α expression and decreased nuclear translocation of p65 NF-κB. Thus, EtOAc from
O. elatus
ARs is involved in regulating MAKP and NF-κB signaling pathways to inhibit LPS-induced inflammation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31529418</pmid><doi>10.1007/s11626-019-00396-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4527-2061</orcidid></addata></record> |
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| identifier | ISSN: 1071-2690 |
| ispartof | In vitro cellular & developmental biology. Animal, 2019-10, Vol.55 (9), p.766-775 |
| issn | 1071-2690 1543-706X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2293002189 |
| source | JSTOR Archival Journals and Primary Sources Collection; Springer Link |
| subjects | Acetic acid Alveoli Animal Genetics and Genomics Animals Biomedical and Life Sciences Bioreactors Bronchus c-Jun protein Cell Biology Cell Culture Developmental Biology Endangered plants Ethyl acetate Herbal medicine Humans In vivo methods and tests Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Interleukin 6 Interleukins JNK protein Kinases Life Sciences Lipopolysaccharides Lipopolysaccharides - toxicity Lung diseases Lungs Macrophages MAP kinase Medicinal plants Metastases Mice Mitogen-Activated Protein Kinase Kinases - genetics NF-kappa B - genetics NF-κB protein Nitric oxide Nitric-oxide synthase Nuclear transport Oplopanax Oplopanax - chemistry Peritoneum Phosphorylation Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Pretreatment Prostaglandin E2 Prostaglandin endoperoxide synthase Proteins Signal transduction Signal Transduction - drug effects Signaling Stem Cells Transcription factors Translocation Tumor necrosis factor-TNF |
| title | Adventitious root cultures of Oplopanax elatus inhibit LPS-induced inflammation via suppressing MAPK and NF-κB signaling pathways |
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