Recent developments of nanoparticle-delivered dosage forms for buccal delivery

The improvement of mucoadhesive buccal formulations has attracted profound interest in recent years. Drug permeability and controlled drug release via this route of administration are still a concern for effective therapy, although various strategies have been proposed. Advanced developments in nano...

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Bibliographic Details
Published in:International journal of pharmaceutics 2019-11, Vol.571, p.118697-118697, Article 118697
Main Authors: Tran, Phuong H.L., Duan, Wei, Tran, Thao T.D.
Format: Article
Language:English
Subjects:
Adhesiveness
Administration, Buccal
Animals
Controlled drug delivery
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - pharmacokinetics
Drug Carriers - chemistry
Drug Development - trends
Drug Evaluation, Preclinical
Drug Liberation
Humans
Inventions - trends
Models, Animal
Mouth Mucosa - metabolism
Mucoadhesive buccal delivery
Multilayer film
Nanomedicine
Nanoparticles - chemistry
Solubility
Tablet
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Summary:The improvement of mucoadhesive buccal formulations has attracted profound interest in recent years. Drug permeability and controlled drug release via this route of administration are still a concern for effective therapy, although various strategies have been proposed. Advanced developments in nanotechnology have been investigated with promising clinical applications. The incorporation of nanoparticles in dosage forms for buccal delivery not only ensures efficient delivery but also reduces side effects to biological systems. Many approaches have been suggested to load and deliver nanoparticles containing drugs to the buccal mucosa both in topical and systemic administrations. This paper describes recent advanced concepts to include nanoparticles in dosage forms with improving drug delivery or targeting. The classification and discussion of these technologies are aimed at providing an overview of current strategies for applying controlled drug delivery. All remarkable findings will encourage innovative nanoparticle-delivered dosage forms for buccal delivery in clinical applications. [Display omitted]
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2019.118697