Effects of lung deflation induced by tiotropium/olodaterol on the cardiocirculatory responses to exertion in COPD

Hyperinflation has been associated with negative cardiocirculatory consequences in patients with chronic obstructive pulmonary disease (COPD). These abnormalities are likely to worsen when the demands for O2 increase, e.g., under the stress of exercise. Thus, pharmacologically-induced lung deflation...

Full description

Saved in:
Bibliographic Details
Published in:Respiratory medicine 2019-10, Vol.157, p.59-68
Main Authors: Berton, Danilo C., Marques, Renata D., Palmer, Brandon, O'Donnell, Denis E., Neder, J.Alberto
Format: Article
Language:English
Subjects:
Abnormalities
Blood flow
Bronchodilation
Bronchodilator
Bronchodilators
Cardiac output
Cardiography
Chronic obstructive pulmonary disease
COPD
Dyspnea
Electrocardiography
Exertion
Fatigue tests
Heart rate
Hemodynamics
Infrared spectra
Infrared spectroscopy
Lung diseases
Lung mechanics
Lungs
Metabolism
Morphology
Muscles
Near infrared radiation
Obstructive lung disease
Oxygenation
Physiology
Quadriceps muscle
Respiration
Stroke
Subgroups
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hyperinflation has been associated with negative cardiocirculatory consequences in patients with chronic obstructive pulmonary disease (COPD). These abnormalities are likely to worsen when the demands for O2 increase, e.g., under the stress of exercise. Thus, pharmacologically-induced lung deflation may improve cardiopulmonary interactions and exertional cardiac output leading to higher limb muscle blood flow and oxygenation in hyperinflated patients with COPD. 20 patients (residual volume = 201.6 ± 63.6% predicted) performed endurance cardiopulmonary exercise tests (75% peak) 1 h after placebo or tiotropium/olodaterol 5/5 μg via the Respimat® inhaler (Boehringer Ingelheim, Ingelheim am Rhein, Germany). Cardiac output was assessed by signal-morphology impedance cardiography. Near-infrared spectroscopy determined quadriceps blood flow (indocyanine green dye) and intra-muscular oxygenation. Tiotropium/olodaterol was associated with marked lung deflation (p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2019.09.006