Glomerular filtration rate, blood pressure and microalbuminuria in adults born SGA: A 5‐year longitudinal study after cessation of GH treatment

Background Growth hormone treatment increases glomerular filtration rate (GFR), as serum IGF‐I stimulates the renin‐angiotensin system. Infants born with a low birth weight have a smaller number of nephrons, which cause a lower GFR, a higher blood pressure and a higher albumin‐to‐creatinine ratio in...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2019-12, Vol.91 (6), p.892-898
Main Authors: Goedegebuure, Wesley J., Kerkhof, Gerthe F., Hokken‐Koelega, Anita C. S.
Format: Article
Language:English
Subjects:
Age
Albumin
Angiotensin
Blood pressure
Creatinine
Gestational age
Glomerular filtration rate
Growth disorders
Growth hormone
Growth hormones
Infants
kidney function
Kidneys
Longitudinal studies
Low-birth-weight
microalbuminuria
Nephrons
Physical growth
Renin
SGA
Small-for-gestational age
Young adults
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Summary:Background Growth hormone treatment increases glomerular filtration rate (GFR), as serum IGF‐I stimulates the renin‐angiotensin system. Infants born with a low birth weight have a smaller number of nephrons, which cause a lower GFR, a higher blood pressure and a higher albumin‐to‐creatinine ratio in early adulthood. Method A total of 261 young adults born SGA, previously treated with growth hormone (SGA‐GH), were longitudinally followed. Glomerular filtration rate, based on serum creatinine levels, was determined at cessation of GH treatment and at 6 months, 2 years and 5 years thereafter. Glomerular filtration rate, blood pressure and urinary albumin‐to‐creatinine ratio at 5 years after cessation of GH were compared with untreated age‐matched controls (56 untreated short subjects born SGA [SGA‐S], 118 subjects born SGA with spontaneous catch‐up growth [SGA‐CU], 135 subjects born appropriate for gestational age [AGA]). Results Glomerular filtration rate decreased significantly only during the first 6 months after cessation of GH treatment, while remaining well within the normal range (124.6 vs 120.2 mL/min/1.73 m2, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14095