Modulation of the 5-HT3A receptor current by desacylbaldrinal

The serotonin (5-hydroxytryptamine) type 3 receptor is an important target in the control of digestive dysfunction such as anorexia and bulimia, and 5-HT 3 receptor antagonists are effective against eating disorder and the early-phase chemotherapy and radiotherapy evoked vomiting. Our previous resea...

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Bibliographic Details
Published in:Natural product research 2021-08, Vol.35 (16), p.2758-2762
Main Authors: Wang, Li-Xia, Chen, Hu-Lan, Yan, Hong-Ling, Tang, Fei, Zhang, Hai, Li, Hong-Xiang, Ye, Qiang, Peng, Cheng, Tan, Yu-Zhu
Format: Article
Language:English
Subjects:
5-HT3A
Anorexia
Anticancer properties
Chemotherapy
desacylbaldrinal
Eating disorders
Radiation therapy
Receptors
Serotonin
Serotonin S3 receptors
Valeriana jatamansi
Vomiting
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Summary:The serotonin (5-hydroxytryptamine) type 3 receptor is an important target in the control of digestive dysfunction such as anorexia and bulimia, and 5-HT 3 receptor antagonists are effective against eating disorder and the early-phase chemotherapy and radiotherapy evoked vomiting. Our previous research of Valeriana jatamansi revealed the presence of iridoids, which showed potent antitumor activities. Here, we explored the effects of 10π aromatic iridoid desacylbaldrinal isolated from V. jatamansi on the 5-HT 3 receptor current. We performed whole cell recordings of 5-HT 3 A receptor currents in the presence of the compound. The result indicated that desacylbaldrinal inhibited the 5-HT-mediated 5-HT 3 A receptor current.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1662009