Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging

Humans and other organisms show age-related signs of deterioration, which makes aging an interesting process to study. In the present work, we review the anti-aging evidence of several of the most promising natural compounds. Quercetin, rapamycin, resveratrol, spermidine, curcumin or sulforaphane ad...

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Bibliographic Details
Published in:Biogerontology (Dordrecht) 2019-10, Vol.20 (5), p.583-603
Main Authors: Gómez-Linton, Darío R., Alavez, Silvestre, Alarcón-Aguilar, Adriana, López-Diazguerrero, Norma E., Konigsberg, Mina, Pérez-Flores, Laura J.
Format: Article
Language:English
Subjects:
Adaptation, Physiological - drug effects
Adaptation, Physiological - physiology
Aging
Aging - drug effects
Aging - physiology
Animals
Biological Products - metabolism
Biological Products - pharmacology
Biomedical and Life Sciences
Cell Biology
Curcumin
Developmental Biology
Geriatrics/Gerontology
Humans
Life Sciences
Longevity
Longevity - drug effects
Longevity - physiology
Models, Biological
Quercetin
Rapamycin
Resveratrol
Review Article
Signal Transduction - drug effects
Signal Transduction - physiology
Spermidine
Sulforaphane
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Summary:Humans and other organisms show age-related signs of deterioration, which makes aging an interesting process to study. In the present work, we review the anti-aging evidence of several of the most promising natural compounds. Quercetin, rapamycin, resveratrol, spermidine, curcumin or sulforaphane administration increase longevity and stress resistance in model organisms such as yeasts, nematodes, flies and mice. Even more, rapamycin, resveratrol, and curcumin are currently in preclinical tests on the Interventions Testing Program of the National Institute on Aging due to their encouraging results in model organisms. The potential mechanisms underlying the beneficial effects of these compounds are briefly described.
ISSN:1389-5729
1573-6768
DOI:10.1007/s10522-019-09817-2