miRNAs as biomarkers of orofacial clefts: A systematic review

Orofacial clefts are facial malformations caused by the improper development of the lips and palate. Many genetic and epigenetic molecules have been involved in the mechanisms of orofacial clefts, one of which are miRNAs. This systematic review aimed to identify miRNAs associated to non‐syndromic or...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2020-03, Vol.49 (3), p.201-209
Main Authors: Mendes, Sissy Maria Dos Anjos, Espinosa, Daybelis Del Socorro González, Moreira, Paulo Eliezer De Oliveira, Marques, Diego, Fagundes, Nathalia Carolina Fernandes, Ribeiro‐dos‐Santos, Ândrea
Format: Article
Language:English
Subjects:
Biomarkers
Cleft Lip - genetics
Cleft lip/palate
Cleft Palate - genetics
craniofacial anomalies
craniofacial biology
Dentistry
Etiology
evidence‐based medicine
gene expression
genetics
Humans
MicroRNAs - genetics
Minority & ethnic groups
miRNA
molecular genetics
Orofacial clefts
Systematic review
Therapeutic applications
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Summary:Orofacial clefts are facial malformations caused by the improper development of the lips and palate. Many genetic and epigenetic molecules have been involved in the mechanisms of orofacial clefts, one of which are miRNAs. This systematic review aimed to identify miRNAs associated to non‐syndromic orofacial clefts in humans. After applying a series of criteria, four studies were selected for analysis. In total, one hundred miRNAs were observed in the literature, of which 57 were reported as upregulated and 43 as downregulated in all orofacial cleft classifications. Moreover, nine miRNAs were differentially expressed only in cleft palate patients, which might suggest distinct regulatory mechanisms for the etiology of cleft lips and palates. We suggest broader population sampling in order to include diverse ethnic groups in the future, as well as analyses toward identifying miRNA target genes and pathways. We highlight the need for experimental validation and of these results to allow further translational approaches and clinical applications.
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.12950