Associations between estimated foetal weight discordance and clinical characteristics within dichorionic twins: The NICHD Fetal Growth Studies

Background Birthweight discordance is well studied, with less known about longitudinal inter‐twin differences in foetal growth. Objective To examine inter‐twin per cent differences in EFW (EFW%), head (HC%) and abdominal circumference (AC%), and femur length (FL%) across gestation in dichorionic twi...

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Bibliographic Details
Published in:Paediatric and perinatal epidemiology 2019-09, Vol.33 (5), p.332-342
Main Authors: Amyx, Melissa M., Albert, Paul S., Bever, Alaina M., Hinkle, Stefanie N., Owen, John, Grobman, William A., Newman, Roger B., Chien, Edward K., Gore‐Langton, Robert E., Buck Louis, Germaine M., Grantz, Katherine L.
Format: Article
Language:English
Subjects:
Adult
Biometrics
Birth weight
Body mass
Body mass index
Body size
Body weight
Confidence intervals
dichorionic
Discordance
Diseases in Twins - diagnostic imaging
Diseases in Twins - pathology
Embryos
estimated foetal weight
Female
Femur
Fertility
Fertilization
Fetal Development - physiology
Fetal Growth Retardation - diagnostic imaging
Fetal Growth Retardation - pathology
Fetal Weight - physiology
Fetuses
foetal growth
Gestation
Gestational Age
Humans
In vitro fertilization
In vitro methods and tests
National Institute of Child Health and Human Development (U.S.)
Neonates
Obesity
Overweight
Ovulation
Predictive Value of Tests
Pregnancy
Pregnancy, Twin
Prenatal Care
twin
twin discordance
Twins
Twins, Dizygotic
Ultrasonography, Prenatal
Ultrasound
Underweight
United States
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Summary:Background Birthweight discordance is well studied, with less known about longitudinal inter‐twin differences in foetal growth. Objective To examine inter‐twin per cent differences in EFW (EFW%), head (HC%) and abdominal circumference (AC%), and femur length (FL%) across gestation in dichorionic twin gestations and explore associated characteristics. Methods Foetal biometrics were assessed by ultrasound and EFW calculated at ≤6 study visits among women with dichorionic twin pregnancies enrolled in the NICHD Fetal Growth Studies cohort (US, 2012‐2013). Inter‐twin per cent difference was defined: ([Sizelarger twin − Sizesmaller twin]/Sizelarger twin × 100). Linear mixed models evaluated per cent differences in foetal biometrics at 15 weeks and their change per week overall and by maternal/neonatal characteristics in unadjusted and adjusted models. Results In 140 pregnancies, inter‐twin per cent differences increased across gestation for EFW (0.18%/week, 95% confidence interval [CI] 0.10, 0.27), HC (0.03%/week, 95% CI 0.00, 0.06), and AC (0.03%/week, 95%CI −0.01, 0.08) but decreased for FL (−0.03%/week, 95% CI −0.09, 0.02). After adjustment, change in EFW% difference across gestation differed by pre‐pregnancy body mass index (BMI [kg/m2]; underweight [
ISSN:0269-5022
1365-3016
DOI:10.1111/ppe.12570