Construction of a biomimetic chemokine reservoir stimulates rapid in situ wound repair and regeneration

[Display omitted] Skin is the first protection of human body. It is always challenged by a range of external factors, resulting in the wounds of skin. Hydrogel, as a dressing with multiple advantages, causes increasing interests or the applications in wound treatment. However, the function and impor...

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Bibliographic Details
Published in:International journal of pharmaceutics 2019-10, Vol.570, p.118648-118648, Article 118648
Main Authors: Xu, Xue-Han, Yuan, Tie-Jun, Ye, Pei-Wu, Wang, Mao-Ze, Ma, Hui-Jian, Jiang, Zhi-Hong, Zhang, Yong-Pin, Peng, Li-Hua
Format: Article
Language:English
Subjects:
Animals
Bandages
Biomimetic hydrogel
Biomimetic Materials - administration & dosage
Biomimetic Materials - chemistry
Biomimetics - methods
Bone Marrow - drug effects
Bone Marrow - metabolism
Chemokine
Chemokines - metabolism
Chitosan - chemistry
Drug Delivery Systems - methods
Humans
Hydrogels - chemistry
Mesenchymal Stem Cells - drug effects
Mesenchymal Stem Cells - metabolism
Moisture microenvironment
Polyvinyl Alcohol - chemistry
Rats
Rats, Sprague-Dawley
Regeneration - drug effects
Skin - drug effects
Skin - metabolism
Topical delivery
Wound Healing - drug effects
Wound repair
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Summary:[Display omitted] Skin is the first protection of human body. It is always challenged by a range of external factors, resulting in the wounds of skin. Hydrogel, as a dressing with multiple advantages, causes increasing interests or the applications in wound treatment. However, the function and importance of micro-environment of wound region are frequently neglected. In this study, we successfully developed a chemokine loaded biomimetic hydrogel as a functional reservoir to stimulate the rapid in situ recruitment of BMSCs for fast wound repair and regeneration. The biomimetic hydrogel was fabricated by using the Polyvinyl alcohol (PVA) combined with chitosan (CS) as the hybrid materials. The fabricated hydrogel possesses many features such as the porous structure, high swelling rate and moisture retention property. More importantly, the incorporated chemokine could be released with a sustained manner from the hydrogel and recruited the bone marrow mesenchymal stem cells (BMSCs) significantly both in vitro & in vivo. Moreover, the hydrogel was demonstrated to be highly biocompatible to the skin tissue without any side effect or irritation observed. Topical delivery of chemokine by the biomimetic PVA/CS hybrid material based hydrogel is demonstrated as a promising carrier to accelerate wound repair and regeneration without inducing scar formation and any other negative complications. The PVA/CS/SDF-1 hydrogel was shown a novel therapeutic system for wound therapy.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2019.118648