Protective effects of Hydrocotyle umbellata var. bonariensis Lam. (Araliaceae) on memory in sleep-impaired female mice

Hydrocotyle umbellata var.bonariensis Lam. (Hb), popularly known in Brazil as acariçoba and outside Brazil Hb by a number of names including marsh-pennywort, and many-flower, has traditionally been used in Ayurvedic medicine in the retardation of aging (Rasayana effect). The present study evaluated...

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Published in:Journal of ethnopharmacology 2019-12, Vol.245, p.112183-112183, Article 112183
Main Authors: Barbosa, C.C., Rodrigues, T.C., Ataídes, C.F.S., Santos, M.L., Ghedini, P.C., Dias Junior, W., Andersen, M.L., Mazaro-Costa, R.
Format: Article
Language:English
Subjects:
Acariçoba
Acetylcholinesterase - metabolism
Animals
Araliaceae
Brain - drug effects
Brain - metabolism
Estrous Cycle - drug effects
Female
Learning - drug effects
Memory
Mice
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Sleep deprivation
Sleep Deprivation - drug therapy
Sleep Deprivation - metabolism
Sleep Deprivation - physiopathology
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Summary:Hydrocotyle umbellata var.bonariensis Lam. (Hb), popularly known in Brazil as acariçoba and outside Brazil Hb by a number of names including marsh-pennywort, and many-flower, has traditionally been used in Ayurvedic medicine in the retardation of aging (Rasayana effect). The present study evaluated the effect of Hb treatment before and during paradoxical sleep deprivation (PSD) and sleep restriction (SR) on learning, memory, and acetylcholinesterase (AChE) brain activity. Adult Swiss nulliparous female mice were randomly distributed among the experimental groups. The treated groups received the aqueous solution of Hb leaves orally at concentrations of 500 and 1.000 mg/kg. PSD and SR were induced by the multiple platform method, in which the animals remained for 3-days in PSD or 15-days in SR for 22 h per day. The collection of the vaginal epithelium occurred daily to determine the estrous cycle. Body mass gain was determined. The animals were submitted to the passive avoidance test and were then euthanized for the collection of brain tissue and the determination of cerebral cholinesterase activity. The aqueous solution of Hb was associated with a significant reduction in cholinesterase activity at both doses in the SR model, and at the dose of 1.000 mg/kg in the PSD model. Regarding the learning and memory test, the PSD group treated with 1.000 mg/kg presented significant improvement, whereas in the SR experiment none of the treated-groups showed any improvement in learning and memory. In the analysis of SR/PSD interference and/or Hb treatment on the estrous cycle, it was possible to observe that the treatment acted as a protector in the SR group, maintaining a normal cycle. The analyses showed that Hb was safe to use during periods of SR or PSD, acting as an adaptogen for these situations, in addition to being able to reduce cholinesterase activity, which suggests its neuroprotective action. In relation to the estrous cycle, Hb can act as a protector in SR situations. [Display omitted]
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2019.112183