Bioactive glass functionalized chondroitin sulfate hydrogel with proangiogenic properties

Blood vessels play an important role in bone defect repair and growth, and a critical challenge of bone defect repair is the promotion of blood vessel formation. Most of the current methods promote vascularization by adding specific growth factors, which are costly and easy to inactivate. In this st...

Full description

Saved in:
Bibliographic Details
Published in:Biopolymers 2019-12, Vol.110 (12), p.e23328-n/a
Main Authors: Zhang, Feng‐Miao, Zhou, Lei, Zhou, Zheng‐Nan, Dai, Cong, Fan, Lei, Li, Chang‐Hao, Xiao, Cai‐Rong, Ning, Cheng‐Yun, Liu, Yi, Du, Jian‐Qiang, Tan, Guo‐Xin
Format: Article
Language:English
Subjects:
Amino groups
Angiogenesis
bioactive glass nanoparticle
Bioglass
Biological activity
Blood vessels
Bone growth
Cell adhesion
Cell adhesion & migration
Chondroitin sulfate
Chondroitin Sulfates - chemistry
Chondroitin Sulfates - pharmacology
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Covalence
Covalent bonds
Deformation resistance
Glass
Growth factors
Human Umbilical Vein Endothelial Cells - cytology
Human Umbilical Vein Endothelial Cells - metabolism
Humans
hydrogel
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Loss modulus
Mechanical properties
Methacrylates - chemistry
Methacrylates - pharmacology
Nanoparticles
Nanoparticles - chemistry
Neovascularization, Physiologic - drug effects
Repair
Storage modulus
surface modification
Surface Properties
Vascularization
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood vessels play an important role in bone defect repair and growth, and a critical challenge of bone defect repair is the promotion of blood vessel formation. Most of the current methods promote vascularization by adding specific growth factors, which are costly and easy to inactivate. In this study, we developed a covalently cross‐linked aminated bioactive glass nanoparticle‐chondroitin sulfate methacrylate (ABGN‐CSMA) organic‐inorganic composite hydrogel with angiogenic properties. The amino groups of the ABGNs form covalent bonds with the carboxyl groups on CSMA. Surface amination modification of BGNs not only improved the dispersion of BGNs in CSMA but also significantly improved the mechanical properties of the composite hydrogel. The largest storage modulus (1200 Pa), the largest loss modulus (560 Pa) and the strongest resistance to deformation of the hydrogel are seen at 10% concentration of ABGNs. Simultaneously, the local pH stability and sustained ion release of the composite hydrogel are conducive to cell adhesion, proliferation, and angiogenesis. This work provides evidence for the development of covalently cross‐linked organic‐inorganic composite hydrogels with angiogenic properties.
ISSN:0006-3525
1097-0282
DOI:10.1002/bip.23328