Obesity and pancreatic cancer: An update of epidemiological evidence and molecular mechanisms

Despite advances in therapy and achievements in translational research, pancreatic cancer (PC) remains an invariably fatal malignancy. Risk factors that affect the incidence of PC include diabetes, smoking, obesity, chronic pancreatitis, and diet. The growing worldwide obesity epidemic is associated...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019-10, Vol.19 (7), p.941-950
Main Authors: Zhou, Bin, Wu, Dong, Liu, Han, Du, Lu-tao, Wang, Yun-shan, Xu, Jian-wei, Qiu, Fa-bo, Hu, San-yuan, Zhan, Han-xiang
Format: Article
Language:English
Subjects:
Adipocytes
Adipose tissue
Age
Alcohol
Bariatric surgery
Body mass index
Body weight loss
Diabetes
Diabetes mellitus
Epidemiology
Gastrointestinal surgery
Gender
Gene Expression Regulation
Health risk assessment
Humans
Inflammation
Insulin Resistance
Lipid metabolism
Lymphatic system
Malignancy
Medical prognosis
Menopause
Meta-analysis
Metabolism
Metastasis
Molecular modelling
Obesity
Obesity - complications
Obesity - epidemiology
Pancreatic cancer
Pancreatic Neoplasms - complications
Pancreatic Neoplasms - epidemiology
Pancreatitis
Pathogenesis
Reviews
Risk Factors
Somatomedins - genetics
Somatomedins - metabolism
Studies
Surgery
Womens health
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Summary:Despite advances in therapy and achievements in translational research, pancreatic cancer (PC) remains an invariably fatal malignancy. Risk factors that affect the incidence of PC include diabetes, smoking, obesity, chronic pancreatitis, and diet. The growing worldwide obesity epidemic is associated with an increased risk of the most common cancers, including PC. Chronic inflammation, hormonal effects, circulating adipokines, and adipocyte-mediated inflammatory and immunosuppressive microenvironment are involved in the association of obesity with PC. Herein, we systematically review the epidemiology of PC and the biological mechanisms that may account for this association. Included in this review is a discussion of adipokine-mediated inflammation, lipid metabolism, and the interactions of adipocytes with cancer cells. We consider the influence of bariatric surgery on the risk of PC risk as well as potential molecular targets of therapy. Our review leads us to conclude that targeting adipose tissue to achieve weight loss may represent a new therapeutic strategy for preventing and treating PC.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2019.08.008