Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan

Background and Aim The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subject...

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Published in:Journal of gastroenterology and hepatology 2020-02, Vol.35 (2), p.233-240
Main Authors: Chen, Mei‐Jyh, Fang, Yu‐Jen, Wu, Ming‐Shiang, Chen, Chieh‐Chang, Chen, Yen‐Nien, Yu, Chien‐Chun, Kuo, Chia‐Chi, Chiu, Min‐Chin, Hu, Wen‐Hao, Tsai, Min‐Horn, Hsieh, Cheng‐Lin, Chen, Hsin‐Hung, Bair, Ming‐Jong, Liou, Jyh‐Ming
Format: Article
Language:English
Subjects:
Accuracy
Adults
Antigens
Dyspepsia
H. pylori stool antigen test
Helicobacter pylori
Infections
Optical density
Prevalence
Serology
Taiwan
Urea
Urease
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Summary:Background and Aim The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subjects and in patients with dyspepsia and to assess the accuracy of H. pylori stool antigen (HpSA) test for screening of H. pylori in Chinese population. Methods Asymptomatic adult subjects (N = 189) were screened for H. pylori infection using HpSA, serology, and 13C‐urea breath test (13C‐UBT) in 2016–2017. Adult patients with dyspepsia (N = 145) were screened for H. pylori using 13C‐UBT, HpSA, serology, rapid urease test, and histology during 2016–2018. Two types of HpSA, including the Diagnostec HpSA ELISA Kit (HpSA ELISA) and Rapid Test Kit (HpSA Rapid), were used in this study. Sensitivity, specificity, and accuracy of the HpSA tests were calculated using the 13C‐UBT as golden standard test. Results The unadjusted prevalence of H. pylori was 21.2% in asymptomatic adults and 37.9% in patients with dyspepsia (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.14828