High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial

Objective Exercise training is recently considered as a trend in adjuvant therapies for cancer patients, but its mechanisms need to be scrutinized further. This study is aimed to test the hypothesis that the patients who perform the high-intensity interval exercise training (HIIT) during hormone the...

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Published in:Journal of cancer research and clinical oncology 2019-10, Vol.145 (10), p.2583-2593
Main Authors: Alizadeh, Ali Mohammad, Isanejad, Amin, Sadighi, Sanambar, Mardani, Mahtab, kalaghchi, Bita, Hassan, Zuhair Mohammad
Format: Article
Language:English
Subjects:
Body fat
Breast cancer
Cancer Research
Cardiorespiratory fitness
Endocrine therapy
Enzyme-linked immunosorbent assay
Family medical history
Fitness training programs
Heart rate
Hematology
Hsp70 protein
IL-1β
Inflammation
Interleukin 10
Interleukin 4
Interleukin 6
Internal Medicine
Interval training
Leukocytes (mononuclear)
Medicine
Medicine & Public Health
Metastases
Oncology
Original Article – Clinical Oncology
Peripheral blood mononuclear cells
Physical training
Serum levels
Skinfold thickness
Tumor necrosis factor-α
γ-Interferon
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Summary:Objective Exercise training is recently considered as a trend in adjuvant therapies for cancer patients, but its mechanisms need to be scrutinized further. This study is aimed to test the hypothesis that the patients who perform the high-intensity interval exercise training (HIIT) during hormone therapy would show improvements in low-grade inflammation and HSP70 compared to the controls receiving standard care. Methods Fifty two non-metastatic and hormone-responsive breast cancer patients were randomly assigned to high-intensity interval exercise (HIIT) ( n  = 26) and usual care ( n  = 26) groups. The HIIT groups participated in a high-intensity interval training protocol on a treadmill 3 days/week for 12 weeks. The training intensity was determined according to the predicted maximal heart rate. Demographic characteristics and medical history were collected via an interviewer-administered questionnaire at the baseline visit. Body fat was estimated based on skinfold thickness measured with calipers on the participant’s nonsurgery side at the triceps, suprailiac crest. V O 2 max was estimated by 1-Mile Rockport Walk Test. Blood samples were collected 48 h before starting the exercise protocol and 48 h after the last exercise session. TNF-α, IL-6, IL-1β, IL-10, and HSP70 levels in serum were measured using the enzyme-linked immunosorbent assay (ELISA) method according to the manufacture’s instruction. Supernatant cytokine concentrations were determined by ELISA for IL-4 and IFN-γ. The data were analyzed by ANCOVA test that the pretest values were considered as covariate at P  ≤ 0.05. Results HIIT improved V O 2 max in the HIIT group compared to the usual care group ( P  = 0.002). The serum levels of TNF-α ( P  = 0.001), IL-6 ( P  = 0.007), and IL-10 ( P  = 0.001) were lower in the HIIT group. The level of IL-4 ( P  = 0.050) in the stimulated peripheral blood mononuclear cells significantly increased in the HIIT group compared to the usual care group. Furthermore, the serum level of the HSP70 was significantly higher in the HIIT group in comparison to the usual care group ( P  = 0.050). The TNF-α/IL-10 ( P  = 0.050) and IL-6/IL-10 ( P  = 0.042) ratios were lower in the HIIT group. Conclusion The results of this study indicated that HIIT has positive impacts on the cardiorespiratory fitness and inflammatory cytokines in the breast cancer patients undergoing hormone therapy.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-019-02996-y