A novel thymol-doped enamel bonding system: Physico-mechanical properties, bonding strength, and biological activity

Over the past decades, the preparation of antibacterial restorative dental adhesives has obtained increasing attention in order to prevent secondary caries. In the present study, a novel essential oil-based antibacterial resin adhesive was prepared and evaluated for dental applications. In this rega...

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Bibliographic Details
Published in:Journal of the mechanical behavior of biomedical materials 2019-12, Vol.100, p.103378-103378, Article 103378
Main Authors: Rezaeian, Zahra, Beigi-Boroujeni, Saeed, Atai, Mohammad, Ebrahimibagha, Mehrnoosh, Özcan, Mutlu
Format: Article
Language:English
Subjects:
Antibacterial activity
Dental resin adhesive
Microshear bond test
Thymol
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Summary:Over the past decades, the preparation of antibacterial restorative dental adhesives has obtained increasing attention in order to prevent secondary caries. In the present study, a novel essential oil-based antibacterial resin adhesive was prepared and evaluated for dental applications. In this regards, thymol, which is a major phenolic component of thyme essential oil, was incorporated into methacrylate resin matrix and its effect on the physico-mechanical and biological properties of the experimental bonding agent was investigated. Mechanical properties were evaluated via measuring flexural strength, flexural modulus and fracture toughness. Degree of conversion (DC%) of monomers was measured using FTIR spectroscopy. Viscoelastic properties of the samples were also determined by dynamic mechanical thermal analysis (DMTA). The bactericidal activity of composite specimens against Streptococcus mutans (ATCC 35668) was determined based on ASTM E 2180–07.MTT assay was performed to investigate the cytocompatibility of samples. Furthermore, the bonding strength of the adhesives was evaluated through microshear bond test on the caries-free extracted human premolar teeth and the mode of failure was investigated by scanning electron microscopy. Thymol-doped resin adhesive exhibited comparable degree of conversion to the control resin adhesive. The plasticizing behavior of thymol slightly decreased the flexural modulus and glass transition temperature of the thymol containing specimens, even though; it caused significant increases in fracture toughness of adhesive. The results represented appropriate antibacterial activity as well as suitable cytocompatibility. Furthermore, the thymol-doped resin adhesive showed comparable adhesive strength to the control. The thymol is extremely compatible with the methacrylate resin restorative system and completely fulfills all requirements of a good bactericidal component in construction of an ideal enamel bonding system. [Display omitted] •Preparation a novel thymol-doped antibacterial dental resin adhesive.•Evaluation of long-lasting antibacterial activity.•Assessment the effect of incorporated thymol on microshear bond strength of dental resin adhesive
ISSN:1751-6161
1878-0180
DOI:10.1016/j.jmbbm.2019.103378