Interaction between the functional SNP rs2070951 in NR3C2 gene and high levels of plasma corticotropin-releasing hormone associates to postpartum depression

Postpartum depression (PPD) is a common mood disorder that occurs after delivery with a prevalence of approximately 10%. Recent reports have related placental corticotropin-releasing hormone (pCRH) to postpartum depressive symptoms. The aim of this study was to determine whether pCRH, ACTH, and cort...

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Published in:Archives of women's mental health 2020-06, Vol.23 (3), p.413-420
Main Authors: Gutiérrez-Zotes, Alfonso, Díaz-Peña, Roberto, Costas, Javier, Martorell, Lourdes, Gelabert, Estel, Sans, Teresa, Navinés, Ricard, Albacar, Glòria, Ímaz, María Luisa, García-Esteve, Luisa, Sanjuan, Julio, Martín-Santos, Rocio, Carracedo, Angel, Vilella, Elisabet
Format: Article
Language:English
Subjects:
ACTH
Adrenocorticotropic hormone
Corticosteroids
Corticotropin releasing hormone
Ethylenediaminetetraacetic acid
Genetic aspects
Genotype & phenotype
Genotypes
Glucocorticoids
Medicine
Medicine & Public Health
Mental depression
Mood
Neurosis
Obstetrics
Original Article
Placenta
Postpartum
Postpartum depression
Pregnancy complications
Psychiatry
Psychotherapy
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Womens health
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Summary:Postpartum depression (PPD) is a common mood disorder that occurs after delivery with a prevalence of approximately 10%. Recent reports have related placental corticotropin-releasing hormone (pCRH) to postpartum depressive symptoms. The aim of this study was to determine whether pCRH, ACTH, and cortisol (measured 48 h after delivery) and glucocorticoid and mineralocorticoid receptor genotypes ( NR3C1 and NR3C2 ) and their interaction are associated with PPD. A longitudinal 32-week prospective study of five hundred twenty-five Caucasian depression-free women that were recruited from obstetric units at two Spanish general hospitals immediately after delivery. Of the women included in the sample, forty-two (8%) developed PPD. A strong association between PPD and the interaction between the pCRH and NR3C2 rs2070951 genotype was observed. The mean level of pCRH in rs2070951GG carriers with PPD was 56% higher than the mean in the CG and CC genotype groups ( P  
ISSN:1434-1816
1435-1102
DOI:10.1007/s00737-019-00989-x