A comparative evaluation of BACT/ALERT FA PLUS and FN PLUS blood culture bottles and BD BACTEC Plus Aerobic and Anaerobic blood culture bottles for antimicrobial neutralization

The performance of BACT/ALERT FA and FN PLUS (FA PLUS and FN PLUS) blood culture bottles with the BACT/ALERT VIRTUO (bioMérieux, Inc., Durham, NC) and BD BACTEC Plus Aerobic and Anaerobic (BD Aerobic and BD Anaerobic) blood culture bottles with the BD BACTEC FX (BD Diagnostics, Sparks, MD) for antim...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2019-12, Vol.38 (12), p.2229-2233
Main Authors: Chung, Yousun, Kim, In-Hee, Han, Minje, Kim, Hyun Soo, Kim, Han-Sung, Song, Wonkeun, Kim, Jae-Seok
Format: Article
Language:English
Subjects:
Aerobiosis
Ampicillin
Anaerobiosis
Anti-Bacterial Agents - metabolism
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteremia - diagnosis
Bacteremia - microbiology
Bacteria - isolation & purification
Bacteria - metabolism
Biomedical and Life Sciences
Biomedicine
Blood
Blood culture
Blood Culture - instrumentation
Bottles
Cefepime
Cefotaxime
Culture
Culture Media
E coli
Gentamicin
Internal Medicine
Klebsiella
Levofloxacin
Medical Microbiology
Meropenem
Methicillin
Microorganisms
Neutralization
Original Article
Piperacillin
Piperacillin-tazobactam
Pseudomonas aeruginosa
Tazobactam
Time Factors
Vancomycin
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Summary:The performance of BACT/ALERT FA and FN PLUS (FA PLUS and FN PLUS) blood culture bottles with the BACT/ALERT VIRTUO (bioMérieux, Inc., Durham, NC) and BD BACTEC Plus Aerobic and Anaerobic (BD Aerobic and BD Anaerobic) blood culture bottles with the BD BACTEC FX (BD Diagnostics, Sparks, MD) for antimicrobial neutralization at peak serum concentration was evaluated. The following antibiotic agents and microbial strains were used: ampicillin, cefepime, cefotaxime, gentamicin, levofloxacin, meropenem, piperacillin-tazobactam, and vancomycin; methicillin-sensitive Staphylococcus aureus , Acinetobacter baumannii , Escherichia coli , Klebsiella pneumoniae , Pseudomonas aeruginosa , and Bacteroides fragilis . The detection rate of FA PLUS bottles was 69.1% (259/375) and that of BD Aerobic bottles was 75.5% (283/375) ( p  = 0.050). In the case of anaerobic culture, the overall detection rate of FN PLUS bottles was 77.0% (231/300) and that of BD Anaerobic bottles was 71.3% (214/300) ( p  = 0.113). The time to detection (TTD) from aerobic culture was 2.8 h shorter in FA PLUS bottles (12.4 h) compared to BD Aerobic bottles (15.2 h) ( p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-019-03663-3