Colorectal cancer: pharmacogenetics support for the correct drug prescription

Pharmacogenetics (PGx) in clinical practice is a tool that the clinician can use to guide, in a personalized way, the most suitable treatment that will be administered to the patient. The objective of this review is to summarize in a practical and accessible rational way, the advances that currently...

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Bibliographic Details
Published in:Pharmacogenomics 2019-07, Vol.20 (10), p.741-763
Main Authors: Olivera, Gladys, Sendra, Luis, Herrero, María José, Puig, Carlos, Aliño, Salvador F
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Cancer therapies
Chemotherapy
clinical implementation
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Consortia
drug label
Drug Prescriptions
Drugs
Experts
Genomes
guidelines
Humans
Medical prognosis
Metastasis
Mutation
Patients
Pharmacogenetics
Pharmacogenetics - methods
pharmGKB
Polymorphism
Polymorphism, Single Nucleotide - genetics
polymorphisms
Precision Medicine - methods
Systematic review
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Summary:Pharmacogenetics (PGx) in clinical practice is a tool that the clinician can use to guide, in a personalized way, the most suitable treatment that will be administered to the patient. The objective of this review is to summarize in a practical and accessible rational way, the advances that currently exist for the application of PGx in colorectal cancer chemotherapy management through the study of the patients’ germline polymorphisms. To define the polymorphisms that can be applied, we rely on three fundamental cornerstones: the recommendations of drug regulatory agencies; the implementation guidelines prepared by expert consortia in PGx and information from clinical annotations (the drug/polymorphism relation) according to the scientific level of evidence assigned by PharmGKB experts.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2019-0041