Prospective multicenter study of the esophageal triamcinolone acetonide‐filling method in patients with subcircumferential esophageal endoscopic submucosal dissection

Background and Aim The esophageal triamcinolone acetonide (TA)‐filling method is a novel local approach for stenosis prevention after extensive esophageal endoscopic submucosal dissection (ESD). We evaluated this method after subcircumferential ESD. Methods We enrolled 20 patients with esophageal ca...

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Bibliographic Details
Published in:Digestive endoscopy 2020-03, Vol.32 (3), p.355-363
Main Authors: Shibagaki, Kotaro, Yuki, Takafumi, Taniguchi, Hideaki, Aimi, Masahito, Miyaoka, Yoichi, Yuki, Mika, Ishimura, Norihisa, Oshima, Naoki, Mishiro, Tsuyoshi, Tamagawa, Yuji, Mikami, Hironobu, Izumi, Daisuke, Yamashita, Noritsugu, Sato, Shuichi, Ishihara, Shunji, Kinoshita, Yoshikazu
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anti-Inflammatory Agents - administration & dosage
Carcinoma - pathology
Carcinoma - surgery
Endoscopic Mucosal Resection - adverse effects
endoscopic submucosal dissection
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
esophageal stenosis
Esophageal Stenosis - epidemiology
Esophageal Stenosis - prevention & control
Female
Humans
Male
Middle Aged
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
prevention
Prospective Studies
Reproducibility of Results
steroid
triamcinolone acetonide
Triamcinolone Acetonide - administration & dosage
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Summary:Background and Aim The esophageal triamcinolone acetonide (TA)‐filling method is a novel local approach for stenosis prevention after extensive esophageal endoscopic submucosal dissection (ESD). We evaluated this method after subcircumferential ESD. Methods We enrolled 20 patients with esophageal cancer requiring subcircumferential ESD in a prospective multicenter study. Esophageal TA filling was carried out 1 day and 1 week after ESD, with follow‐up endoscopy every 2 weeks. We treated severe stenosis preventing endoscope passage with endoscopic balloon dilatation (EBD) and additional TA filling, and mild stenosis allowing endoscope passage with additional TA filling only. Primary endpoint was incidence of severe stenosis; secondary endpoints were total number of EBD, rate of additional TA filling, time to stenosis and complete re‐epithelialization, dysphagia score, and adverse events. Horizontal resection grade was divided into grades 1 (≥ 9/12 and
ISSN:0915-5635
1443-1661
DOI:10.1111/den.13496