Cascade Alkynylation and Highly Selective Hydrogenation Catalyzed by Binaphthyl-Palladium Nanoparticles Accessing Phosphinyl (Z)‑[3]Dendralenes

A cascade alkynylation and selective hydrogenation catalyzed by covalent binaphthyl-stabilized palladium nanoparticles has been established, providing a novel and highly efficient methodology for accessing Z and Z,Z-selective phosphinyl [3]­dendralenes with broad functional group tolerance and good...

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Bibliographic Details
Published in:Organic letters 2019-08, Vol.21 (16), p.6383-6387
Main Authors: Xia, Yun-Tao, Wu, Jin-Jin, Zhang, Cheng-Yun, Mao, Mao, Ji, Yi-Gang, Wu, Lei
Format: Article
Language:English
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Summary:A cascade alkynylation and selective hydrogenation catalyzed by covalent binaphthyl-stabilized palladium nanoparticles has been established, providing a novel and highly efficient methodology for accessing Z and Z,Z-selective phosphinyl [3]­dendralenes with broad functional group tolerance and good yields. This strategy achieves the first cascade reactions of alkynylation and hydrogenation with chemoselectivity modulated by catalyst loading.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b02287