Lancemaside A from Codonopsis lanceolata prevents hypertension by inhibiting NADPH oxidase 2‐mediated MAPK signalling and improving NO bioavailability in rats

Objectives This study investigated whether lancemaside A (LMA) can prevent hypertension and assessed the mechanisms of action of LMA in rats. Methods Hypertension was induced by chronic immobilization stress and nicotine administration. Hypertensive vehicle rats were treated with LMA (1, 20, or 40 m...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2019-09, Vol.71 (9), p.1458-1468
Main Authors: Shin, You Kyoung, Han, A Young, Hsieh, Yu Shan, Kwon, Soonho, Kim, Jinhye, Lee, Kwang‐Won, Seol, Geun Hee
Format: Article
Language:English
Subjects:
Activation
Animals
antihypertension
Aorta
Aorta - drug effects
Aorta - pathology
Bioavailability
Blood pressure
Blood Pressure - drug effects
Codonopsis
CYBB protein
Endothelial Cells - drug effects
Hypertension
Hypertension - drug therapy
Hypertension - metabolism
Hypertension - psychology
Immobilization
Isoforms
Kinases
lancemaside A
Male
Malondialdehyde
MAP kinase
MAPK
NAD(P)H oxidase
NADPH oxidase
NADPH Oxidase 2 - antagonists & inhibitors
NADPH Oxidase 2 - metabolism
NADPH-diaphorase
Nicotinamide
Nicotinamide adenine dinucleotide
Nifedipine
Nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Synthase Type III - metabolism
Nitric-oxide synthase
NO bioavailability
Oxidase
Oxidative stress
Oxidative Stress - physiology
Protein kinase
Rats, Sprague-Dawley
Saponins - chemistry
Saponins - pharmacology
Signal Transduction
Stress, Psychological
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Summary:Objectives This study investigated whether lancemaside A (LMA) can prevent hypertension and assessed the mechanisms of action of LMA in rats. Methods Hypertension was induced by chronic immobilization stress and nicotine administration. Hypertensive vehicle rats were treated with LMA (1, 20, or 40 mg/kg) or nifedipine (10 mg/kg) as a positive control daily for 3 weeks. Key findings In hypertensive vehicle rats, LMA dose‐dependently reduced systolic blood pressure. LMA doses of 20 and 40 mg/kg reduced the aortic expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)2 (both P 
ISSN:0022-3573
2042-7158
DOI:10.1111/jphp.13140