Serologic survey of the Crimean-Congo haemorrhagic fever virus infection among wild rodents in Hungary

Crimean-Congo haemorrhagic fever virus (CCHFV) is a tick-borne pathogen, which causes an increasing number of severe infections in many parts of Africa, Asia and in Europe. The virus is primarily transmitted by ticks, however, the spectrum of natural hosts regarding CCHFV includes a wide variety of...

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Bibliographic Details
Published in:Ticks and tick-borne diseases 2019-10, Vol.10 (6), p.101258-101258, Article 101258
Main Authors: Földes, Fanni, Madai, Mónika, Németh, Viktória, Zana, Brigitta, Papp, Henrietta, Kemenesi, Gábor, Bock-Marquette, Ildikó, Horváth, Győző, Herczeg, Róbert, Jakab, Ferenc
Format: Article
Language:English
Subjects:
Animals
Antibody
Arvicolinae
Epidemiology
Europe
Female
Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification
Hemorrhagic Fever, Crimean - epidemiology
Hemorrhagic Fever, Crimean - veterinary
Hemorrhagic Fever, Crimean - virology
Hungary - epidemiology
Immunization
Male
Murinae
Nairoviridae
Prevalence
Rodent Diseases - epidemiology
Rodent Diseases - virology
Seroepidemiologic Studies
Tick
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Summary:Crimean-Congo haemorrhagic fever virus (CCHFV) is a tick-borne pathogen, which causes an increasing number of severe infections in many parts of Africa, Asia and in Europe. The virus is primarily transmitted by ticks, however, the spectrum of natural hosts regarding CCHFV includes a wide variety of domestic and wild animals. Although the presence of CCHFV was hypothesized in Hungary, data in support of CCHFV prevalence has thus far, proven insufficient. In the present study, rodents belonging to four species, the yellow-necked mouse (Apodemus flavicollis), the striped field mouse (A. agrarius), the wood mouse (A. sylvaticus) and the bank vole (Myodes glareolus), were all systematically trapped in the Mecsek Mountain region (Southwest Hungary), from 2011 through 2013. Rodent sera were collected and screened for CCHFV antibodies with dot-blot pre-screening and immunofluorescence assay. Among the 2085 tested rodents, 20 (0.96%) were positive for IgG antibody against CCHFV. Seroprevalence was the highest (1.25%) in A. flavicollis serum samples. Distinctly, we now provide the first data regarding CCHFV occurrence and seroprevalence among wild rodents in Hungary. This observation represents a need for large-scale surveillance to effectively assess the enzootic background and the potential public health risk of CCHFV in Hungary.
ISSN:1877-959X
1877-9603
DOI:10.1016/j.ttbdis.2019.07.002