Biomonitoring Of Genotoxic Risk Of Workers Exposed To Heavy Air Pollution

Epidemiological studies found an increased risk of cancers in occupations exposed to traffic air pollution. PM2.5 are toxic and can enter into the respiratory tract and circulatory system. PM2.5 can adsorb various substances, such as polycyclic aromatic hydrocarbons (PAHs) nitro-PAHs. The present st...

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Bibliographic Details
Published in:WIT Transactions on Ecology and the Environment 2015-01, Vol.198, p.117
Main Authors: Rainho, C R, Correa, S M, Aiub, C A F, Felzenszwalb, I
Format: Article
Language:English
Subjects:
Air pollution
Biological properties
Biological samples
Biomonitoring
Buccal mucosa
Circulatory system
Creatinine
Epidemiology
Exposure
Genotoxicity
Health risks
Informed consent
Lymphocytes
Metabolites
Naphthol
Occupational exposure
Occupations
Particulate matter
Peripheral blood
Pollutants
Pollution
Polycyclic aromatic hydrocarbons
Respiratory tract
Urine
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Summary:Epidemiological studies found an increased risk of cancers in occupations exposed to traffic air pollution. PM2.5 are toxic and can enter into the respiratory tract and circulatory system. PM2.5 can adsorb various substances, such as polycyclic aromatic hydrocarbons (PAHs) nitro-PAHs. The present study was carried out with 15 Reboucas tunnel (Rio de Janeiro, Brazil) workers (exposed group) and 11 healthy men (control group). The participants were informed about the study and asked to sign an informed consent form and to complete a standard questionnaire to obtain necessary data on their lifestyle. Samples of buccal mucosa cells and peripheral blood were evaluated using micronucleus (MN) assay. Urine samples were used to estimate the concentration of 1-hydroxyprene (1-HOP) and 2-naphthol (2-NAP). A significantly higher frequency (10.82) of MN in buccal cells and (4.42) binucleated lymphocytes were detected for the exposed workers. Higher concentrations of 1-HOP (16.47 mu mol/mol creatinine) and 2-NAP (6.56 mu mol/mol creatinine) were also detected in the exposure group. In conclusion, damage to the genetic material and the high concentrations of metabolites of PAHs detected in the biological samples taken from Reboucas tunnel workers can be related to daily exposure to pollutants in the tunnel.
ISSN:1746-448X
1743-3541
DOI:10.2495/AIR150101