Influence of the physical exercise on decrease in the gastric emptying and alter appetite and food behavior in rats dexamethasone-treatment

The chronic use of Dexamethasone (Dex) induced hyperglycemia and insulin resistance. On the other hand, physical exercise attenuates the symptoms induced by Dex in many physiological systems. However, the effect of the exercise on the changes in gastric motility induced by dexamethasone remains unkn...

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Published in:Physiology & behavior 2019-10, Vol.209, p.112610-112610, Article 112610
Main Authors: de Oliveira, Lúcia Castro Santos, Telles, Pedro Victor Nogueira, e Sousa, Jessica Fernanda Reis, Cavalcante, Ana Karolina Martins, Wong, Deysi Viviana Tenazoa, Lima-Junior, Roberto Cesar, Torres-Leal, Francisco Leonardo, dos Santos, Armenio Aguiar, da Silva, Moisés Tolentino Bento
Format: Article
Language:English
Subjects:
Dexamethasone
Exercise
Feeding behavior
Gastric emptying
Hyperglycemia
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Summary:The chronic use of Dexamethasone (Dex) induced hyperglycemia and insulin resistance. On the other hand, physical exercise attenuates the symptoms induced by Dex in many physiological systems. However, the effect of the exercise on the changes in gastric motility induced by dexamethasone remains unknown. We hypothesized that low-intensity aerobic exercise modulates the metabolic effects induced by Dex-treatment by modifying the gastrointestinal function and feeding behavior in rats. Male rats were distributed into the following groups: Control (Ctrl), Dex (1.0 mg/kg, i.p.), Exercise (Ctrl + Exercise 5%) and (Dex1.0 + Exercise 5%). The exercise protocol was swimming for 5 consecutive days. We assessed the murinometric and nutritional indices, food intake, blood glucose by (ipGTT) and the gastric emptying rate of a liquid test meal were assessed in all rats. We observed a significant decrease (p 
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2019.112610