Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults

Background Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. Subjects and Methods We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass i...

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Published in:Pediatric diabetes 2019-11, Vol.20 (7), p.849-860
Main Authors: Ehrmann, David A., Temple, Karla A., Rue, Abby, Barengolts, Elena, Mokhlesi, Babak, Van Cauter, Eve, Sam, Susan, Miller, M. Annette, Kahn, Steven E., Atkinson, Karen M., Palmer, Jerry P., Utzschneider, Kristina M., Gebremedhin, Tsige, Kernan-Schloss, Abigail, Kozedub, Alexandra, Montgomery, Brenda K., Morse, Emily J., Mather, Kieren J., Garrett, Tammy, Hannon, Tamara S., Lteif, Amale, Patel, Aniket, Chisholm, Robin, Moore, Karen, Pirics, Vivian, Pratt, Linda, Nadeau, Kristen J., Gross, Susan, Zeitler, Philip S., Williams, Jayne, Green, Melanie Cree, Garcia Reyes, Yesenia, Vissat, Krista, Arslanian, Silva A., Brown, Kathleen, Guerra, Nancy, Porter, Kristin, Caprio, Sonia, Savoye, Mary, Pierpont, Bridget, Buchanan, Thomas A., Xiang, Anny H., Trigo, Enrique, Beale, Elizabeth, Hendee, Fadi N., Katkhouda, Namir, Nayak, Krishan, Martinez, Mayra, Montgomery, Cortney, Wang, Xinhui, Edelstein, Sharon L., Lachin, John M., Hogan, Ashley N., Marcovina, Santica, Harting, Jessica, Albers, John, Hill, Dave, Savage, Peter J., Leschek, Ellen W.
Format: Article
Language:English
Subjects:
adult
Adults
Age
Blood pressure
Body mass index
Cardiovascular diseases
cardiovascular risk
Cholesterol
Clinical trials
Hemoglobin
High density lipoprotein
Insulin
Insulin resistance
Low density lipoprotein
Obesity
Risk factors
Surgery
youth
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Summary:Background Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. Subjects and Methods We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6.0 kg/m2, hemoglobin A1c [HbA1c] 38.5 ± 6.1 mmol/mol) and 355 adults with comparable BMI (age 52.7 ± 9.4 years, BMI 35.1 ± 5.1 kg/m2, HbA1c 39.8 ± 4.2 mmol/mol) participating in a multicenter study. Insulin sensitivity was quantified using hyperglycemic clamps. Assessment of CV risk factors was standardized across sites. Regression analyses compared the impact of insulin sensitivity and CV risk factors between youth and adults. Results Obese pubertal youth were more insulin resistant than comparably obese adults (P
ISSN:1399-543X
1399-5448
DOI:10.1111/pedi.12883