Copper-Catalyzed Decarboxylative Difluoromethylation

We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-conta...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2019-07, Vol.141 (29), p.11398-11403
Main Authors: Zeng, Xiaojun, Yan, Wenhao, Zacate, Samson B, Chao, Tzu-Hsuan, Sun, Xiaodong, Cao, Zhi, Bradford, Kate G. E, Paeth, Matthew, Tyndall, Sam B, Yang, Kundi, Kuo, Tung-Chun, Cheng, Mu-Jeng, Liu, Wei
Format: Article
Language:English
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Summary:We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products. Mechanistic studies support the involvement of alkyl radicals.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.9b05363