Infection by Leishmania (Leishmania) infantum chagasi causes intestinal changes B‐1 cells dependent

Evaluating the histopathological and morphometric changes caused by Leishmania (Leishmania) infantum chagasi infection either in the presence or absence of B‐1 cells. Wild‐type Balb/c and XID mice were used. Half of XID mice received B‐1 cells adoptive transfer (XID + B1). Five animals from each gro...

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Bibliographic Details
Published in:Parasite immunology 2019-09, Vol.41 (9), p.e12661-n/a
Main Authors: Souza, Karine Delgado, Fernandes, Ellenn Pollyanna Alexandre, Santos, Amanda Gubert Alves, Lima, Lainy Leiny, Gonzaga, Wagner Francisco Kennerly Marcondes, Xander, Patricia, Nogueira‐Melo, Gessilda de Alcantara, Sant'Ana, Débora de Mello Gonçales
Format: Article
Language:English
Subjects:
Adoptive Transfer
Animals
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - pathology
B‐1 cells
Enterocytes
Female
Goblet cells
Ileum
Immunity, Innate
Infections
intestinal mucosal
Intestine
Intestines - cytology
Intestines - immunology
Leishmania
Leishmania infantum - physiology
Leishmaniasis, Visceral - immunology
Leishmaniasis, Visceral - parasitology
Leishmaniasis, Visceral - pathology
Lymphocytes B
Mice
Mice, Inbred BALB C
Paneth cells
small intestine
visceral leishmaniasis
X-Linked Combined Immunodeficiency Diseases - immunology
X-Linked Combined Immunodeficiency Diseases - parasitology
X-Linked Combined Immunodeficiency Diseases - pathology
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Summary:Evaluating the histopathological and morphometric changes caused by Leishmania (Leishmania) infantum chagasi infection either in the presence or absence of B‐1 cells. Wild‐type Balb/c and XID mice were used. Half of XID mice received B‐1 cells adoptive transfer (XID + B1). Five animals from each group were infected (Balb/c I, XID I and XID + B1 I), totalizing six groups (n = 5). After 45 days of infection, the ileum was collected for histological processing and analysis. After infection, the XID animals showed an increase in the thickness of the intestinal layers, in the depth and width of the crypt and in the villi width. However, the Balb/c I group showed a reduction in almost all these parameters, whereas the villi width was increased. The villi height decreased in the infected XID animals; however, it was increased in the XID + B1 I group. Leishmania (L) infantum chagasiinfection caused a decrease in the number of Paneth cells; however, their area was increased. Finally, goblet cells and enterocytes presented different change profiles among groups. This study showed that the parasite infection causes structural and histopathological alterations in the intestine. These changes might be influenced by the absence of B‐1 cells.
ISSN:0141-9838
1365-3024
DOI:10.1111/pim.12661