Non‐invasive screening using ventilatory gas analysis to distinguish between chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

ABSTRACT Background and objective Clinical presentations associated with chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) at rest are highly similar. Differentiating between CTEPH and PAH using non‐invasive techniques remains challenging. Thus, we exami...

Full description

Saved in:
Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2020-04, Vol.25 (4), p.427-434
Main Authors: Akizuki, Mina, Sugimura, Koichiro, Aoki, Tatsuo, Kakihana, Takaaki, Tatebe, Shunsuke, Yamamoto, Saori, Sato, Haruka, Satoh, Kimio, Shimokawa, Hiroaki, Kohzuki, Masahiro
Format: Article
Language:English
Subjects:
Carbon dioxide
cardiovascular diseases
Catheterization
Hypertension
Mechanical ventilation
Perfusion
Posture
pulmonary circulation, pulmonary hypertension
pulmonary gas exchange
Pulmonary hypertension
pulmonary ventilation
Respiratory function
Thromboembolism
Ventilation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background and objective Clinical presentations associated with chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) at rest are highly similar. Differentiating between CTEPH and PAH using non‐invasive techniques remains challenging. Thus, we examined whether analysis of ventilatory gas in response to postural changes can be useful as a non‐invasive screening method for pulmonary hypertension (PH), and help differentiate CTEPH from PAH. Methods We prospectively enrolled 90 patients with suspected PH and performed right heart catheterization, ventilation/perfusion scan and ventilatory gas analysis. Various pulmonary function parameters were examined in the supine and sitting postures, and postural changes were calculated (Δ(supine − sitting)). Results In total, 25 patients with newly diagnosed PAH, 40 patients with newly diagnosed CTEPH and 25 non‐PH patients were included. ΔEnd‐tidal CO2 pressure (PETCO2) was significantly lower in patients with CTEPH and PAH than in non‐PH patients (both P 
ISSN:1323-7799
1440-1843
DOI:10.1111/resp.13618