Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice and yam phytopathogens

Two cyclotetrapeptides, henceforth named Provipeptides A (1) and B (2), along with five known diketopiperazines (3-7) were isolated from the liquid culture of marine Streptomyces sp. 161a recovered from a sample of sea grass Bryopsis sp. The structures of cyclotetrapeptides and diketopiperazines (DK...

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Bibliographic Details
Published in:Journal of antibiotics 2019-10, Vol.72 (10), p.744-751
Main Authors: Betancur, Luz A, Forero, Abel M, Romero-Otero, Adriana, Sepúlveda, Lady Yohanna, Moreno-Sarmiento, Nubia C, Castellanos, Leonardo, Ramos, Freddy A
Format: Article
Language:English
Subjects:
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
Antibiotics
Antimicrobial agents
Bacteria
Burkholderia - drug effects
Chromatography
Colletotrichum - drug effects
Culture Media - chemistry
Dioscorea - microbiology
Metabolites
Microbial Sensitivity Tests
Microorganisms
Molecular Structure
Natural products
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Oryza - microbiology
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pesticides
Rice
Spectrum Analysis
Streptomyces - growth & development
Streptomyces - metabolism
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Summary:Two cyclotetrapeptides, henceforth named Provipeptides A (1) and B (2), along with five known diketopiperazines (3-7) were isolated from the liquid culture of marine Streptomyces sp. 161a recovered from a sample of sea grass Bryopsis sp. The structures of cyclotetrapeptides and diketopiperazines (DKPs) were established by 1D and 2D NMR data, MS, and by comparison with literature data. The absolute stereochemistry of compounds cyclo-(L-Pro-L-Leu-D-Pro-L-Phe) 1 and cyclo-(-Pro-Ile-Pro-Phe) 2 was established by the Marfey's method. Compound 1 showed antibacterial activity against rice phytopathogenic strains Burkholderia glumae (MIC = 1.1 mM) and Burkholderia gladioli (MIC = 0.068 mM), compound 2 was active only against B. glumae (MIC = 1.1 mM), and DKP cyclo-[L-Pro-L-Leu] 5 showed to be active against B. gladioli (MIC = 0.3 mM) and B. glumae (MIC = 2.4 mM). Compounds 1 and 2 showed 65% and 50% inhibition of Colletotrichum gloeosporioides (yam pathogen) conidia germination, respectively at a concentration of 1.1 mM.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-019-0201-0