Oriented attachment of VNAR proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid–polyethylene glycol (PL...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019, Vol.55 (53), p.7671-7674
Main Authors: Nogueira, João C F, Greene, Michelle K, Richards, Daniel A, Furby, Alexander O, John, Steven, Porter, Andrew, Barelle, Caroline, Scott, Christopher J, Chudasama, Vijay
Format: Article
Language:English
Subjects:
Antigens
Drug delivery systems
Glycolic acid
Lactic acid
Nanoparticles
Organic chemistry
Polyethylene glycol
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Summary:Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid–polyethylene glycol (PLGA–PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c9cc02655j