Extrapulmonary associations of health status in severe asthma and bronchiectasis: Comorbidities and functional outcomes

Severe asthma and bronchiectasis are heterogeneous diseases that contribute to disability beyond the pulmonary system. The magnitude of the impact that these extrapulmonary features has on health-related quality of life (HRQoL) is unknown. We analysed the cross-sectional relationships between HRQoL...

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Bibliographic Details
Published in:Respiratory medicine 2019-07, Vol.154, p.93-101
Main Authors: Cordova-Rivera, Laura, Gibson, Peter G., Gardiner, Paul A., Hiles, Sarah A., McDonald, Vanessa M.
Format: Article
Language:English
Subjects:
Ambulatory care
Anxiety
Asthma
Bone density
Bronchiectasis
Chronic obstructive pulmonary disease
Comorbidity
Domains
Exercise
Females
Health-related quality of life
Inflammation
Isometric
Leg
Males
Mental depression
Musculoskeletal system
Osteoporosis
Patients
Physical activity
Quality of life
Questionnaires
Sarcopenia
Severe asthma
Signs and symptoms
Strength
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Summary:Severe asthma and bronchiectasis are heterogeneous diseases that contribute to disability beyond the pulmonary system. The magnitude of the impact that these extrapulmonary features has on health-related quality of life (HRQoL) is unknown. We analysed the cross-sectional relationships between HRQoL (St. George's Respiratory Questionnaire; SGRQ) and extrapulmonary characteristics, including physical activity (steps/day), anxiety and depression, isometric leg strength, systemic inflammation, and several comorbidities in adults with severe asthma (n = 70) and bronchiectasis (n = 61). Participants with severe asthma and bronchiectasis had similar SGRQ total scores (mean scores 43.7 and 37.8 for severe asthma and bronchiectasis; p > 0.05), and similar pulmonary and extrapulmonary characteristics. The associations between extrapulmonary variables and HRQoL did not differ according to diagnosis (all interactions p > 0.05). Greater anxiety and depressive symptoms, fewer steps/day and greater systemic inflammation were statistically associated with poorer HRQoL in both diseases (p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2019.06.010