KH-Domain Poly(C)-Binding Proteins as Versatile Regulators of Multiple Biological Processes

Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include regulation of gene transcription, regulation of pre-mRNA processing, splicing, mRNA stability, translational silencing and enhancement, the co...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2019-03, Vol.84 (3), p.205-219
Main Authors: Nazarov, I. B., Bakhmet, E. I., Tomilin, A. N.
Format: Article
Language:English
Subjects:
Animals
Binding
Binding proteins
Biochemistry
Biological activity
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cancer
Cell differentiation
Cell regulation
Control stability
Deregulation
Differentiation (biology)
Embryogenesis
Embryonic growth stage
Gene expression
Gene regulation
Heterogeneous-Nuclear Ribonucleoprotein K - metabolism
Humans
Iron
Life Sciences
Mechanical properties
Microbiology
mRNA processing
mRNA stability
Nucleic acids
Observations
Pluripotency
Pluripotent Stem Cells - metabolism
Post-transcription
Protein interaction
Proteins
Review
Splicing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include regulation of gene transcription, regulation of pre-mRNA processing, splicing, mRNA stability, translational silencing and enhancement, the control of iron turnover, and many others. Mechanistically, these proteins act via nucleic acid binding and protein–protein interactions. Through performing these multiple tasks, the KH-domain poly(C)-binding family members are involved in a wide variety of biological processes such as embryonic development, cell differentiation, and cancer. Deregulation of KH-domain protein expression is frequently associated with severe developmental defects and neoplasia. This review summarizes progress in studies of the KH-domain proteins made over past two decades. The review also reports our recent finding implying an involvement of the KH-factor Pcbp1 into control of transition from naive to primed pluripotency cell state.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297919030039