How Much Is Needed? Comparison of the Effectiveness of Different Pain Education Dosages in Patients with Fibromyalgia

Abstract Objective To assess the effect of different dosages of pain neuroscience education (PNE) programs on central nociceptive processing in patients with fibromyalgia. Second, to compare the effects of different dosages of PNE programs on numerical pain rating scale (NPRS), disability, and psych...

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Published in:Pain medicine (Malden, Mass.) Mass.), 2020-04, Vol.21 (4), p.782-793
Main Authors: Amer-Cuenca, Juan J, Pecos-Martín, Daniel, Martínez-Merinero, Patricia, Lluch Girbés, Enrique, Nijs, Jo, Meeus, Mira, Ferrer Peña, Raúl, Fernández-Carnero, Josué
Format: Article
Language:English
Subjects:
Adult
Aged
Anxiety - psychology
Catastrophization - physiopathology
Dosage
Educational aspects
Female
Fibromyalgia
Fibromyalgia - physiopathology
Fibromyalgia - psychology
Fibromyalgia - therapy
Humans
Male
Methods
Middle Aged
Nervous system
Neurosciences
Nociception
Pain
Pain management
Pain Measurement
Pain Perception
Pain Threshold
Patient education
Patient Education as Topic - methods
Postsynaptic Potential Summation
Pressure
Psychological aspects
Single-Blind Method
Time Factors
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Summary:Abstract Objective To assess the effect of different dosages of pain neuroscience education (PNE) programs on central nociceptive processing in patients with fibromyalgia. Second, to compare the effects of different dosages of PNE programs on numerical pain rating scale (NPRS), disability, and psychological variables. Design Single-blind randomized controlled trial. Setting Three fibromyalgia centers in Spain (Valencia, Alcorcón, Alcalá de Henares). Subjects Seventy-seven patients with fibromyalgia. Methods Participants were randomized to four groups of PNE: 1) high-dose PNE (N = 20), 2) low–concentrated dose PNE (N = 20), 3) diluted low-dose PNE (N = 20), and (4) control treatment (N = 17), conducted in two 30–50-minute sessions in groups of four to six participants. Conditioned pain modulation (CPM), temporal summation (TS), and pressure pain thresholds (PPTs) were assessed at baseline and at three-month follow-up. Secondary outcome measures were the Fibromyalgia Impact Questionnaire, Pain Catastrophizing Scale, and Pain Anxiety Symptoms Scale. Results There were significant between-group differences for NPRS in favor of the groups receiving high-dose PNE, with a large effect size at three-month follow-up (P  0.05). All groups improved for central nociceptive processing, psychological variables, disability, and pain intensity (NPRS). Conclusions In patients with fibromyalgia, higher dosages of PNE produced a larger improvement in pain severity at three-month follow-up than other dosages of PNE and biomedical education. However, PNE was not superior to biomedical education in the central nociceptive processing, disability, or psychological variables in patients with fibromyalgia.
ISSN:1526-2375
1526-4637
DOI:10.1093/pm/pnz069