Formyl-peptide receptor 2 suppresses proliferation, migration and invasion in human extravillous trophoblastic cells

•Formyl-peptide receptor 2 suppresses proliferation, migration and invasion in human extravillous trophoblastic cells.•The inhibitory role of FPR2 on human extravillous trophoblastic cells via ILK/NF-κB signaling.•These finding indicated that ideal FPR2 levels are important for TEV-1 cells functions...

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Published in:Prostaglandins & other lipid mediators 2019-08, Vol.143, p.106342-106342, Article 106342
Main Authors: Zhao, Shenzhi, Liao, Tingting, Zhou, Tong, Huang, Xianping, Xiang, Huiqiu, Chen, Jiajia, Xu, Zhangye
Format: Article
Language:English
Subjects:
Cell Line
Cell Movement - drug effects
Cell Proliferation - drug effects
Extravillous trophoblastic cells
Formyl peptide receptor-2
Humans
Lipoxin A4
Lipoxins - pharmacology
Matrix Metalloproteinase 9 - metabolism
NF-kappa B - metabolism
Protein-Serine-Threonine Kinases - metabolism
Receptors, Formyl Peptide - metabolism
Receptors, Lipoxin - metabolism
Signal Transduction - drug effects
Trophoblasts - cytology
Vascular Endothelial Growth Factor A - metabolism
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Summary:•Formyl-peptide receptor 2 suppresses proliferation, migration and invasion in human extravillous trophoblastic cells.•The inhibitory role of FPR2 on human extravillous trophoblastic cells via ILK/NF-κB signaling.•These finding indicated that ideal FPR2 levels are important for TEV-1 cells functions. Although FPR2 receptor is distributed in the endometrium and placenta, its function in human extravillous trophoblastic (TEV-1) cells still remains enigmatic. In this study, overexpression of FPR2 was performed in TEV-1 cells. Then, CCK8 transwell and wound healing assays were used to assess the cell proliferation, migration and invasion, respectively. The results showed that FPR2 overexpression significantly inhibited proliferation, invasion and migration in TEV-1 cells. In addition, FPR2 overexpression significantly decreased mRNA and protein levels of integrin-linked kinase (ILK), nuclear factor-kappa B (NF--κB), matrix metalloproteinase 9 (MMP9) and vascular endothelial growth factor (VEGF) in TEV-1 cells. These findings indicated that FPR2 overexpression alters proliferation, migration and invasion in human extravillous trophoblastic cellsthrough the ILK/NF-κB signaling pathway; ideal FPR2 levels are important for TEV-1 cells functions.
ISSN:1098-8823
DOI:10.1016/j.prostaglandins.2019.106342