Presence of Hepatitis B virus DNA in follicular fluid in female Hepatitis B carriers and outcome of IVF/ICSI treatment: A prospective observational study

To determine the relationship between the presence of detectable HBV DNA in the follicular fluid in HBV carriers with IVF/ICSI treatment outcome. A prospective observational study conducted in the Assisted Reproductive Unit, a tertiary referral centre affiliated with the Department of Obstetrics and...

Full description

Saved in:
Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2019-08, Vol.239, p.11-15
Main Authors: Mak, Jennifer S.M., Leung, Maran B.W., Chung, Cathy H.S., Chung, Jacqueline P.W., Cheung, L.P., Lao, Terence T, Li, T.C.
Format: Article
Language:English
Subjects:
Adult
Blastocyst rate
DNA, Viral - isolation & purification
Female
Follicular Fluid - virology
Hepatitis B - complications
Hepatitis B - virology
Hepatitis B virus infection
Humans
In vitro fertilization
Infertility, Female - virology
Pregnancy
Pregnancy Rate
Prospective Studies
Sperm Injections, Intracytoplasmic - statistics & numerical data
Viable embryos
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To determine the relationship between the presence of detectable HBV DNA in the follicular fluid in HBV carriers with IVF/ICSI treatment outcome. A prospective observational study conducted in the Assisted Reproductive Unit, a tertiary referral centre affiliated with the Department of Obstetrics and Gynecology, The Chinese University of Hong Kong; and the Union Reproductive Medicine Centre at Union Hospital, Hong Kong. The primary outcome measure was pregnancy rate. Secondary outcome measures were the prevalence of detectable HBV DNA in the follicular fluid, implantation rate, clinical pregnancy rate, ongoing pregnancy rate and live birth rate. HBV DNA was detected in the follicular fluid of 28 (43.8%) of the 64 women, and the mean level in this group in log10 copies/mL (±SD) was 4.36 ± 1.85. Women with detectable follicular fluid HBV DNA were younger, lighter, had longer duration of infertility, higher incidence of detectable serum HBV DNA (OR 4.592, 95% C I 2.333–9.038), and significantly wider range in the number of total fertilized, viable embryos, and blastocyst rate, but no difference in cycle characteristics, stimulation and pregnancy outcomes, although the almost doubled ongoing pregnancy/live birth rate per cycle initiated (60.7% versus 38.9%) failed to reach statistical significance due to the small numbers. Our results suggested HBV infection did not appear to be detrimental to the outcome of IVF/ICSI treatment.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2019.05.029