Scutellarin inhibits hypoxia‐induced epithelial‐mesenchymal transition in bladder cancer cells

Scutellarin, an active component of flavonoid, displays a variety of physiological actions and has been applied for the treatment of diverse diseases including hypertension and cerebral infarction as well as cerebral thrombosis. In recent time, Scutellarin has been demonstrated to possess the antica...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular physiology 2019-12, Vol.234 (12), p.23169-23175
Main Authors: Lv, Wei‐Ling, Liu, Qian, An, Ji‐Hong, Song, Xiao‐Yong
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Anticancer properties
Antitumor activity
Biological activity
Bladder
Bladder cancer
bladder cancer (BC)
Cell adhesion & migration
Cell migration
Cerebral infarction
epithelial‐mesenchymal transition (EMT)
Flavonoids
Hypertension
Hypoxia
Infarction
MAP kinase
Medical treatment
Mesenchyme
Metastases
Scutellarin
Thromboembolism
Thrombosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Scutellarin, an active component of flavonoid, displays a variety of physiological actions and has been applied for the treatment of diverse diseases including hypertension and cerebral infarction as well as cerebral thrombosis. In recent time, Scutellarin has been demonstrated to possess the anticancer activity. But the biological significance of Scutellarin in bladder cancer (BC) remains to be elucidated. In the current study, we explored the specific effect of Scutellarin on BC progression. We found that Scutellarin inhibited hypoxia‐induced BC cell migration and invasion in vitro as well as suppressed hypoxia‐induced BC metastasis in vivo. Moreover, Scutellarin significantly reversed hypoxia‐promoted epithelial‐mesenchymal transition (EMT) in BC cells and the PI3K/Akt and MAPK pathways were implicated in the suppressive effect. Taken together, we suggested the potential value of Scutellarin as a novel anticancer agent for BC treatment. Scutellarin inhibited hypoxia‐induced bladder cancer (BC) cell migration and invasion in vitro as well as suppressed hypoxia‐induced BC cell metastasis in vivo. Moreover, Scutellarin significantly reversed hypoxia‐induced EMT in BC cells and the PI3K/Akt and MAPK pathways were implicated in the suppressive effect.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28883