Ultrasound detected changes in joint cartilage thickness in juvenile idiopathic arthritis

Aim The purpose of this study was to investigate the changes in joint cartilage thickness in different subtypes of juvenile idiopathic arthritis (JIA) using ultrasound, comparing them with healthy children and to evaluate the relationship with disease duration and inflammatory markers. Methods We co...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2019-07, Vol.22 (7), p.1263-1270
Main Authors: Mitra, Sonali, Samui, Partha Pratim, Samanta, Moumita, Mondal, Rakesh Kumar, Hazra, Avijit, Mandal, Kalyanbrata, Sabui, Tapas Kumar
Format: Article
Language:English
Subjects:
Age Factors
Ankle
Ankle Joint - diagnostic imaging
Arthritis
Arthritis, Juvenile - diagnostic imaging
Cartilage
Cartilage, Articular - diagnostic imaging
Case-Control Studies
Child
Child, Preschool
Children
Cross-Sectional Studies
Female
Humans
joint cartilage
Joint diseases
juvenile idiopathic arthritis
Knee
Knee Joint - diagnostic imaging
Male
Population studies
Predictive Value of Tests
Sex Factors
Ultrasonic imaging
Ultrasonography
Ultrasound
Wrist
Wrist Joint - diagnostic imaging
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Summary:Aim The purpose of this study was to investigate the changes in joint cartilage thickness in different subtypes of juvenile idiopathic arthritis (JIA) using ultrasound, comparing them with healthy children and to evaluate the relationship with disease duration and inflammatory markers. Methods We conducted a cross‐sectional study comprising of 27 cases of JIA and 54 age‐ and sex‐matched healthy children. Bilateral wrist, knee and ankle joint cartilage thicknesses were measured by ultrasound as per European League Against Rheumatism standard guidelines and compared them between JIA subtypes as well as between cases and control. Results Descriptive analysis of the whole cohort revealed the mean age of the study population was 8.3 ± 3.2 years with mean cartilage thicknesses at the wrist, knee and ankle being 1.40 ± 0.89 mm, 1.57 ± 0.78 mm and 1.41 ± 0.85 mm, respectively. The median cartilage thicknesses of wrist, knee and ankle joints of JIA cases (n = 27) and healthy controls (n = 54) were 1.01, 1.35, 1.05 and 1.95, 2.00, 1.95, respectively. The joint cartilage thickness was significantly reduced in JIA in comparison to the healthy cohort (P 
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.13584