Tumor safety and side effects of photobiomodulation therapy used for prevention and management of cancer treatment toxicities. A systematic review

•Photobiomodulation therapy is effective in the management of cancer treatment toxicities.•Photobiomodulation therapy acceptance is limited by its potential increase of tumor recurrences.•Photobiomodulation therapy is not associated with side effects in cancer patients.•Photobiomodulation therapy be...

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Published in:Oral oncology 2019-06, Vol.93, p.21-28
Main Authors: de Pauli Paglioni, Mariana, Araújo, Anna Luíza Damaceno, Arboleda, Lady Paola Aristizábal, Palmier, Natalia Rangel, Fonsêca, Jéssica Montenegro, Gomes-Silva, Wagner, Madrid-Troconis, Cristhian Camilo, Silveira, Felipe Martins, Martins, Manoela Domingues, Faria, Karina Morais, Ribeiro, Ana Carolina Prado, Brandão, Thaís Bianca, Lopes, Marcio Ajudarte, Leme, Adriana Franco Paes, Migliorati, César Augusto, Santos-Silva, Alan Roger
Format: Article
Language:English
Subjects:
Cancer
Cancer treatment toxicities
Humans
Laser
Low-Level Light Therapy
Lymphedema - etiology
Lymphedema - prevention & control
Lymphedema - radiotherapy
Mucositis
Neoplasms - therapy
Photobiomodulation
Randomized Controlled Trials as Topic
Safety
Side effect
Stomatitis - etiology
Stomatitis - prevention & control
Stomatitis - radiotherapy
Systematic review
Treatment Outcome
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Summary:•Photobiomodulation therapy is effective in the management of cancer treatment toxicities.•Photobiomodulation therapy acceptance is limited by its potential increase of tumor recurrences.•Photobiomodulation therapy is not associated with side effects in cancer patients.•Photobiomodulation therapy benefits are independent of the risk that enhances tumor behaviors. Photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), has been increasingly used for the treatment of toxicities related to cancer treatment. One of the challenges for the universal acceptance of PBMT use in cancer patients is whether or not there is a potential for the light to stimulate the growth of residual malignant cells that evaded oncologic treatment, increasing the risk for tumor recurrences and development of a second primary tumor. Current science suggests promising effects of PBMT in the prevention and treatment of breast cancer-related lymphedema and oral mucositis, among other cancer treatment toxicities. Nevertheless, this seems to be the first systematic review to analyze the safety of the use of PBMT for the management of cancer-related toxicities. Scopus, MEDLINE/PubMed, and Embase were searched electronically. A total of 27 articles met the search criteria. Selected studies included the use of PBMT for prevention and treatment of oral mucositis, lymphedema, radiodermatitis, and peripheral neuropathy. Most studies showed that no side effects were observed with the use of PBMT. The results of this systematic review, based on current literature, suggest that the use of PBMT in the prevention and management of cancer treatment toxicities does not lead to the development of tumor safety issues.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2019.04.004