Microbial production of cyanophycin: From enzymes to biopolymers

Cyanophycin is an attractive biopolymer with chemical and material properties that are suitable for industrial applications in the fields of food, medicine, cosmetics, nutrition, and agriculture. For efficient production of cyanophycin, considerable efforts have been exerted to characterize cyanophy...

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Bibliographic Details
Published in:Biotechnology advances 2019-11, Vol.37 (7), p.107400-107400, Article 107400
Main Authors: Du, Jikun, Li, Li, Zhou, Shining
Format: Article
Language:English
Subjects:
Bacterial Proteins - biosynthesis
Biopolymers
Cosmetics
CphA
Cyanobacteria
Cyanophycin
E coli
Enzymes
Industrial applications
Material properties
Microorganisms
Nutrition
Organic chemistry
Peptide Synthases
Plant Proteins
Production
Pseudomonas putida
Yeast
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Summary:Cyanophycin is an attractive biopolymer with chemical and material properties that are suitable for industrial applications in the fields of food, medicine, cosmetics, nutrition, and agriculture. For efficient production of cyanophycin, considerable efforts have been exerted to characterize cyanophycin synthetases (CphAs) and optimize fermentations and downstream processes. In this paper, we review the characteristics of diverse CphAs from cyanobacteria and non-cyanobacteria. Furthermore, strategies for cyanophycin production in microbial strains, including Escherichia coli, Pseudomonas putida, Ralstonia eutropha, Rhizopus oryzae, and Saccharomyces cerevisiae, heterologously expressing different cphA genes are reviewed. Additionally, chemical and material properties of cyanophycin and its derivatives produced through biological or chemical modifications are reviewed in the context of their industrial applications. Finally, future perspectives on microbial production of cyanophycin are provided to improve its cost-effectiveness. •Notable events and advances in cyanophycin research are introduced.•Characteristics of representative cyanophycin synthetases are presented.•Strategies for cyanophycin production in microbial strains are reviewed.•Chemical and material properties of cyanophycin are summarized.•Current and potential applications of cyanophycin are discussed.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2019.05.006