Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence

Excessive physical exercise (overtraining; OT) increases oxidative stress and induces damage in multiple organs including the brain, especially the hippocampus that plays an important role in learning and memory. Silibinin, a natural flavonoid derived from milk thistle of Silybum marianum , has been...

Full description

Saved in:
Bibliographic Details
Published in:Neurochemical research 2019-08, Vol.44 (8), p.1818-1829
Main Authors: Liu, Bo, Liu, Weiwei, Liu, Panwen, Liu, Xiumin, Song, Xiaoyu, Hayashi, Toshihiko, Onodera, Satoshi, Ikejima, Takashi
Format: Article
Language:English
Subjects:
Aging - drug effects
Animals
Apoptosis
Apoptosis - drug effects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain damage
Catalase - metabolism
Cell Biology
Defects
Exercise
Hippocampus
Hippocampus - pathology
Learning
Male
Malondialdehyde
Malondialdehyde - metabolism
Maze Learning - drug effects
Memory Disorders - drug therapy
Neurochemistry
Neurology
Neuroprotection
Neuroprotective Agents - therapeutic use
Neurosciences
Object recognition
Organs
Original Paper
Overtraining
Oxidative stress
Oxidative Stress - drug effects
Pattern recognition
Physical Conditioning, Animal - adverse effects
Physical exercise
Rats, Sprague-Dawley
Reactive oxygen species
Rodents
Senescence
Silibinin
Silybin - therapeutic use
Superoxide Dismutase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Excessive physical exercise (overtraining; OT) increases oxidative stress and induces damage in multiple organs including the brain, especially the hippocampus that plays an important role in learning and memory. Silibinin, a natural flavonoid derived from milk thistle of Silybum marianum , has been reported to exert neuroprotective effect. In this study, rats were subjected to overtraining exercise, and the protective effects of silibinin were investigated in these models. Morris water maze and novel object recognition tests showed that silibinin significantly attenuated memory defects in overtrained rats. At the same time, the results of Nissl, TUNEL and SA-β-gal staining showed that silibinin reversed neuronal loss caused by apoptosis, and delayed cell senescence of the hippocampus in the overtrained rats, respectively. In addition, silibinin decreased malondialdehyde (MDA) levels which is associated with reactive oxygen species (ROS) generation. Silibinin prevented impairment of learning and memory caused by excessive physical exercise in rats, accompanied by reduced apoptosis and senescence in hippocampus cells.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-019-02816-2