Polyradiculoneuropathy in dourine-affected horses

•The pathogenesis of neurological clinical signs of dourine has been unclear.•The pathogenesis was investigated by histopathology in four dourine-afflicted horses.•Multifocal radiculoneuropathy was observed in the dourine-afflicted horses.•Neuropathy may be responsible for the neurological clinical...

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Published in:Neuromuscular disorders : NMD 2019-06, Vol.29 (6), p.437-443
Main Authors: Mungun-Ochir, Bayasgalan, Horiuchi, Noriyuki, Altanchimeg, Adilbish, Koyama, Kenji, Suganuma, Keisuke, Nyamdolgor, Uranbileg, Watanabe, Ken-ichi, Baatarjargal, Purevdorj, Mizushima, Daiki, Battur, Banzragch, Yokoyama, Naoaki, Battsetseg, Badgar, Inoue, Noboru, Kobayashi, Yoshiyasu
Format: Article
Language:English
Subjects:
Dourine
Polyradiculoneuropathy
Trypanosoma equiperdum
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Summary:•The pathogenesis of neurological clinical signs of dourine has been unclear.•The pathogenesis was investigated by histopathology in four dourine-afflicted horses.•Multifocal radiculoneuropathy was observed in the dourine-afflicted horses.•Neuropathy may be responsible for the neurological clinical signs of dourine. Dourine is an equine protozoan disease caused by Trypanosoma equiperdum. Dourine-afflicted animals die after developing neurological clinical signs, such as unilateral paresis. The disease has been a problem for many years; however, the pathogenesis regarding the neurological clinical signs of dourine has been unclear. In the present study, we conducted a histopathological examination in order to investigate the mechanisms by which dourine-afflicted horses develop the accompanying neurological clinical signs. Four dourine-afflicted horses in Mongolia were evaluated. An apparently healthy horse exhibited multifocal neuritis without axonal or myelin degeneration. The other horses, which had obvious neurological clinical signs, also exhibited multifocal neuritis. In particular, the nerves that innervated areas associated with neurological clinical signs exhibited neuritis with demyelination in the latter horses. Inflamed, non-demyelinating nerves were infiltrated with B lymphocytes and T lymphocytes; while inflamed, demyelinating nerves were infiltrated with mononuclear phagocytes. Our observations revealed lesion progression in the nerves, such that polyradiculoneuropathy could explain the accompanying neurological clinical signs of dourine. To our knowledge, this is the first report to describe a pathogenic mechanism for the development of the neurological clinical signs found in dourine-afflicted horses.
ISSN:0960-8966
1873-2364
DOI:10.1016/j.nmd.2019.03.005