Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial

Type 2 diabetes mellitus (T2DM) is associated with premature atherosclerosis and arterial stiffening due to the accumulation of advanced glycation end-products in vessel walls. Green tea polyphenols are considered cardio-protective substances. In this randomised double-blind placebo-controlled trial...

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Published in:International journal of food sciences and nutrition 2019-11, Vol.70 (8), p.977-985
Main Authors: Quezada-Fernández, Patricia, Trujillo-Quiros, Jhonatan, Pascoe-González, Sara, Trujillo-Rangel, Walter A., Cardona-Müller, David, Ramos-Becerra, Carlos G., Barocio-Pantoja, Maricruz, Rodríguez-de la Cerda, Mariana, Nérida Sánchez-Rodríguez, Esther, Cardona-Muñóz, Ernesto G., García-Benavides, Leonel, Grover-Páez, Fernando
Format: Article
Language:English
Subjects:
Adult
Advanced glycosylation end products
Alanine Transaminase - blood
arterial stiffness
Arteriosclerosis
Aspartate Aminotransferases - blood
Atherosclerosis
Blood vessels
Body composition
Body Composition - drug effects
Body Mass Index
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Creatinine - blood
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Dietary Supplements
Double-Blind Method
Double-blind studies
Epigallocatechin gallate
Female
Food science
Glycated Hemoglobin A - metabolism
Glycosylation
Green tea
Green tea extract
Hemodynamics - drug effects
Hormone replacement therapy
Humans
Lipid Metabolism - drug effects
lipid profile
Lipids
Male
Middle Aged
Placebo effect
Plant Extracts - pharmacology
Polyphenols
Polyphenols - administration & dosage
Randomization
Receptor for Advanced Glycation End Products - blood
S100 Proteins - blood
sRAGE
Statins
Stiffening
Stiffness
Tea
Tea - chemistry
Therapy
Triglycerides - blood
type 2 diabetes mellitus
Vascular Stiffness - drug effects
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Summary:Type 2 diabetes mellitus (T2DM) is associated with premature atherosclerosis and arterial stiffening due to the accumulation of advanced glycation end-products in vessel walls. Green tea polyphenols are considered cardio-protective substances. In this randomised double-blind placebo-controlled trial (NCT02627898), we evaluated the effect of Green tea extract on arterial stiffness parameters, lipids, body composition and sRAGE levels. Twenty normotensive patients with T2DM treated with the standard therapy and statins, mean age 53.2 ± 9.4 years and mean BMI 30.1 ± 4.5 kg/m 2 , were randomised to receive a daily dose of 400 mg of green tea extract (polyphenols ≥90%, EGCG ≥45%) or placebo for 12 weeks. Compared to placebo, administration of green tea extract decreased central augmentation index (-3.05 ± 10.8% vs. 6.7 ± 0.1%, p = .04). These findings suggest that green tea extract could be used as an adjunct to the standard therapy to improve arterial stiffness in T2DM.
ISSN:0963-7486
1465-3478
DOI:10.1080/09637486.2019.1589430