Prevalence, Concordance, and Transmission of Human Papillomavirus Infection Among Heterosexual Couples in Liuzhou, China: An Observational Perspective Study

Knowledge of human papillomavirus (HPV) transmission dynamics, which have important public health implications for designing HPV vaccination strategies, is scarce in undeveloped areas. From May to July 2014, 390 couples were enrolled from the general population in Liuzhou, China. Exfoliated cells fr...

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Bibliographic Details
Published in:The Journal of infectious diseases 2019-08, Vol.220 (6), p.980-989
Main Authors: Su, Yingying, Wei, Feixue, Huang, Xiumin, Li, Yafei, Qiu, Lingxian, Hu, Fangfang, Yang, Chaoqi, Zhang, Yuejing, Yin, Kai, Li, Mingqiang, Wu, Ting, Xia, Ningshao, Zhang, Jun
Format: Article
Language:English
Subjects:
Anal Canal - virology
Anogenital
China - epidemiology
Cohort Studies
Disease transmission
Female
Females
Genitalia, Female - virology
Genitalia, Male - virology
Glans penis
Heterosexuality
Human papillomavirus
Humans
Male
Males
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
Papillomavirus Infections - transmission
Penis
Penis - virology
Prevalence
Public health
Sexual Behavior
Vaccination
Vagina
Vagina - virology
Vulva
Vulva - virology
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Summary:Knowledge of human papillomavirus (HPV) transmission dynamics, which have important public health implications for designing HPV vaccination strategies, is scarce in undeveloped areas. From May to July 2014, 390 couples were enrolled from the general population in Liuzhou, China. Exfoliated cells from male penis shaft/glans penis/coronary sulcus (PGC) and perianal/anal canal (PA) sites and from female vaginal, vulvar, and PA sites were collected biannually for 1 year. The HPV type-specific concordance rate between couples was 15.5% (95% confidence interval [CI], 8.5%-25.0%). For anogenital HPV transmission, the male-to-female transmission rate (11.5 [95% CI, 4.3-30.7] per 1000 person-months) was similar to the female-to-male transmission rate (11.3 [95% CI, 5.9-21.7] per 1000 person-months). The concordance rates between male PGC site and female vaginal, vulvar, and PA sites were 20.0%, 21.8%, and 14.9%, respectively, which were significantly higher than expected by chance. Infections transmitted from males to females seemed mainly originated from male genital sites, whereas for female-to-male transmission, the vaginal, vulvar, and PA sites might be all involved. Among the heterosexual couples with relatively conservative sexual behavior, the anogenital HPV transmission rate for females to males is similar to that of males to females. In addition to the vagina and vulva, the female PA site is also an important reservoir for HPV transmission.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiz224