Spanish list of potentially inappropriate drugs in the elderly (ES-PIA project)

Purpose In the last decades, different criteria have been developed for detecting inappropriate prescription in older patients. In Spain, translations and adaptations of international lists are available but it would be necessary a national list which could cope with the peculiarities of our health...

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Published in:European journal of clinical pharmacology 2019-08, Vol.75 (8), p.1161-1176
Main Authors: Gonzalez-Colaço Harmand, Magali, Aldea-Perona, Ana María, Boada-Fernández del Campo, Carlos, Areosa-Sastre, Almudena, Rodríguez-Jiménez, Consuelo, García Sánchez-Colomer, Marcelino, Fernández Quintana, Eduardo, Plasencia-Nuñez, Mercedes, Masiero-Aparicio, Paula, Grillo-Grillo, Candelaria, Orellana-Mobilli, Andrés, García Sáiz, Mar, Duarte Diéguez, Carmen, Hornillos Calvo, Mercedes, Avellana Zaragoza, Juan Antonio, Martínez Velilla, Nicolás, de Guzmán Pérez Hernández, Domingo, Ruiz González, Mario, Blanco Reina, Encarnación, Asensio Ostos, Carmen, Peiró, Ana, Cabrera García, Lourdes, Hortigüela Moro, Fuensanta, Pérez Alayón, Herlinda, Espárrago García, Iriana, Santana Quilez, Javier, Alonso Ramírez, Javier, Fernández Oropesa, Carlos, López Varona, Mª José, Acín Gerico, Mª Teresa, Sanz Alvarez, Emilio, Martín de la Sierra, María Ángeles, Peñalver, María José, Falomir Gómez, Teresa, Ruiz Salazar, Jesús, Rivas, Gabriela Elizondo, Rey Rodríguez, Edmundo
Format: Article
Language:English
Subjects:
Adaptation
Age Factors
Aged
Aged, 80 and over
Agreements
Biomedical and Life Sciences
Biomedicine
Delphi method
Delphi Technique
Geriatrics
Heterogeneity
Humans
Inappropriate Prescribing - prevention & control
Older people
Pharmacoepidemiology and Prescription
Pharmacology
Pharmacology/Toxicology
Pharmacovigilance
Potentially Inappropriate Medication List
Questionnaires
Sentences
Spain
Surveys and Questionnaires
Translations
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Summary:Purpose In the last decades, different criteria have been developed for detecting inappropriate prescription in older patients. In Spain, translations and adaptations of international lists are available but it would be necessary a national list which could cope with the peculiarities of our health system, existing pharmaceutical market, and prescription habits. We propose in this project the creation of a Spanish potentially inappropriate drugs list which could be applicable in our clinical scenario. Methods We use a Delphi method involving 25 experts from different backgrounds (Clinical Pharmacology, Geriatrics, Rational Use of Drugs and Pharmacy, Primary Care and Pharmacoepidemiology, and Pharmacovigilance) that were asked to participate in two-round questionnaires. For analysis, current recommendations of Worth and Pigni were applied, and every statement was classified into one of three groups: strong, moderate, or low agreement. Statements with strong agreement were accepted to be part of the inadequate prescription list. Moderate agreement statements were selected to enter the second questionnaire, and statements with low agreement were further analyzed to determine if it was due to heterogeneity or due to dispersion in the answers. Results The first questionnaire consisted of 160 proposed sentences, of which 106 reached a high agreement, 32 a moderate agreement, and 22 a low agreement. All sentences proposed in the second questionnaire reached a strong agreement. The total accepted sentences were 138. Conclusions We offer a list of inadequate prescription in older patients adapted to the Spanish pharmacopeia and according to the prescription habits in our environment.
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-019-02684-3