Metabolic Checkpoint of Immune Cells in Melanoma Brain Metastases

Metabolic features of both cancer cells and immune cells shift with nutrient availability in the tumor microenvironment, resulting in differential effects on antitumor immune function. The work of Fischer and colleagues demonstrates that increased oxidative phosphorylation in brain metastases in pat...

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Published in:Cancer discovery 2019-05, Vol.9 (5), p.581-583
Main Authors: Egelston, Colt A, Margolin, Kim
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Language:English
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description Metabolic features of both cancer cells and immune cells shift with nutrient availability in the tumor microenvironment, resulting in differential effects on antitumor immune function. The work of Fischer and colleagues demonstrates that increased oxidative phosphorylation in brain metastases in patients with melanoma is a key regulator of intracranial immune surveillance and that inhibition of oxidative phosphorylation could reduce the incidence of intracranial brain metastases in a murine model of melanoma. .
doi_str_mv 10.1158/2159-8290.CD-19-0249
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title Metabolic Checkpoint of Immune Cells in Melanoma Brain Metastases
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