Metabolic Checkpoint of Immune Cells in Melanoma Brain Metastases

Metabolic features of both cancer cells and immune cells shift with nutrient availability in the tumor microenvironment, resulting in differential effects on antitumor immune function. The work of Fischer and colleagues demonstrates that increased oxidative phosphorylation in brain metastases in pat...

Full description

Saved in:
Bibliographic Details
Published in:Cancer discovery 2019-05, Vol.9 (5), p.581-583
Main Authors: Egelston, Colt A, Margolin, Kim
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolic features of both cancer cells and immune cells shift with nutrient availability in the tumor microenvironment, resulting in differential effects on antitumor immune function. The work of Fischer and colleagues demonstrates that increased oxidative phosphorylation in brain metastases in patients with melanoma is a key regulator of intracranial immune surveillance and that inhibition of oxidative phosphorylation could reduce the incidence of intracranial brain metastases in a murine model of melanoma. .
ISSN:2159-8274
2159-8290
DOI:10.1158/2159-8290.CD-19-0249