The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis

It has previously been reported in a European case-control study with patients from Germany and France that CEL-HYB1, a hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene CELP, increases susceptibility to chronic pancreatitis (CP). Here, we aimed to replicate this finding in Po...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019-06, Vol.19 (4), p.531-534
Main Authors: Oracz, Grzegorz, Kujko, Aleksandra Anna, Fjeld, Karianne, Wertheim-Tysarowska, Katarzyna, Adamus-Białek, Wioletta, Steine, Solrun Johanne, Koziel, Dorota, Gluszek, Stanislaw, Molven, Anders, Rygiel, Agnieszka Magdalena
Format: Article
Language:English
Subjects:
Abuse
Adolescent
Age
Age of Onset
Alleles
Carrier State
Case-Control Studies
CEL-HYB1 allele
Child
Child, Preschool
Chronic pancreatitis
Cohort Studies
Data collection
Deoxyribonucleic acid
DNA
Families & family life
Female
Gene Frequency
Genes
Genetic testing
Humans
Infant
Lipase
Lipase - genetics
Male
Mutation
Pancreatitis
Pancreatitis, Chronic - epidemiology
Pancreatitis, Chronic - genetics
Patients
Pediatrics
Poland - epidemiology
Polymerase Chain Reaction
Proteins
Smoking
Statistical analysis
Studies
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Summary:It has previously been reported in a European case-control study with patients from Germany and France that CEL-HYB1, a hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene CELP, increases susceptibility to chronic pancreatitis (CP). Here, we aimed to replicate this finding in Polish pediatric patients with CP. The distribution of the CEL-HYB1 allele in a CP pediatric cohort (n = 147, median age at CP onset 7.6 years) with no history of alcohol/smoking abuse was compared with ethnically matched healthy controls (n = 500, median age 46 years). Screening was performed using long-range PCR followed by agarose gel-electrophoresis. We observed no significant difference in the carrier frequency of the CEL-HYB1 allele between CP patients (7/147, 4.8%) and controls (12/500, 2.4%; P = 0.16). This study found no statistically significant association between CEL-HYB1 and chronic pancreatitis in a cohort of Polish pediatric CP patients.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2019.04.006