A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Fifty-two subjects with MCI were blindly randomized to...

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Bibliographic Details
Published in:Alzheimer's & dementia 2019-05, Vol.15 (5), p.625-634
Main Authors: Fortier, Mélanie, Castellano, Christian-Alexandre, Croteau, Etienne, Langlois, Francis, Bocti, Christian, St-Pierre, Valérie, Vandenberghe, Camille, Bernier, Michaël, Roy, Maggie, Descoteaux, Maxime, Whittingstall, Kevin, Lepage, Martin, Turcotte, Éric E., Fulop, Tamas, Cunnane, Stephen C.
Format: Article
Language:English
Subjects:
Acetoacetate
Aged
Alzheimer's disease
Beta-hydroxybutyrate
Brain - metabolism
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - metabolism
Decanoic acid
Energy Metabolism - physiology
Female
Fluorodeoxyglucose
Fluorodeoxyglucose F18 - metabolism
Glucose
Glucose - metabolism
Humans
Ketone
Ketones - administration & dosage
Ketones - metabolism
Male
Medium chain triglyceride
Mild cognitive impairment
Neuropsychological Tests - statistics & numerical data
Octanoic acid
PET imaging
Positron-Emission Tomography
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Summary:Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Fifty-two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later. Brain ketone metabolism increased by 230% for subjects on the kMCT (P 
ISSN:1552-5260
1552-5279
DOI:10.1016/j.jalz.2018.12.017